Evidence map›Paper›PMID 39215031›Full record

ArticleNature communications2024

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K

Lea C Neelsen, Elena B Riel, Susanne Rinné, Freya-Rebecca Schmid, Björn C Jürs, Mauricio Bedoya, Jan P Langer, Bisher Eymsh, Aytug K Kiper, Sönke Cordeiro and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Structural basis for proton inhibition of the two-pore domain KStructure (London, England : 1993) · 2026
    Article
  3. The diabetes-associated KDiabetologia · 2026
    Article
  4. Article
  5. Gating mechanism of the two-pore-domain potassium channel THIK1.Nature structural & molecular biology · 2025
    Article
  6. Quetiapine competitively inhibits 5-HTThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lea C Neelsen *Institute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany.
Elena B Riel *Institute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany.ORCID 0000-0003-3227-9344
Susanne Rinné *Institute of Physiology and Pathophysiology, Philipps-University of Marburg, Marburg, Germany.ORCID 0000-0003-2326-7069
Freya-Rebecca SchmidDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.
Björn C JürsInstitute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany.ORCID 0000-0002-2459-6799
Mauricio BedoyaCentro de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca, Chile.ORCID 0000-0002-3542-7528
Jan P LangerInstitute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany.
Bisher EymshInstitute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany.
Aytug K KiperInstitute of Physiology and Pathophysiology, Philipps-University of Marburg, Marburg, Germany.ORCID 0000-0003-2850-2523
Sönke CordeiroInstitute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany.
Niels DecherInstitute of Physiology and Pathophysiology, Philipps-University of Marburg, Marburg, Germany. decher@staff.uni-marburg.de.ORCID 0000-0002-9433-687X
Thomas BaukrowitzInstitute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany. t.baukrowitz@physiologie.uni-kiel.de.ORCID 0000-0003-4562-0505
Marcus ScheweInstitute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany. m.schewe@physiologie.uni-kiel.de.ORCID 0000-0002-6192-5651

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SCHE 2112/1-2
6 · The paper itself

Abstract

Two-pore domain K

Indexed as

Ion Channel GatingPotassium Channels, Tandem Pore DomainAnimalsCytoplasmHEK293 CellsHumansIonsMutationXenopus laevisIonsKCNK17 protein, humanPotassium Channels, Tandem Pore Domain

Identifiers

PMID39215031
PMCPMC11364775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.