ArticleNature communications2024
A catalog of small proteins from the global microbiome.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Gut microbial signatures in poultry under low-protein diets and lysine restriction: implications for precision nutrition.Veterinary and animal science · 2026Review
- Bacterial small regulatory RNAs.Nature reviews. Microbiology · 2026Review
- Dual Activity Microbial Peptides Catalog.Scientific data · 2026Article
- microntology: a lightweight, data-driven controlled vocabulary to describe earth's microbial habitats.Bioinformatics (Oxford, England) · 2026Article
- High-resolution multi-omics enhances prediction and detection of smORF-encoded proteins in the human gut microbiome.Nature communications · 2026Article
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- iSymBase: an integrative functional-genomic platform for ecological exploration of insect symbionts.ISME communications · 2026Article
- Predicted bacterial uRBSs reveal translational coupling and ribosome-mediated RBS occlusion as gene-controlling mechanisms.microLife · 2026Article
- TPT: a compact CNN-transformer encoder for efficient microbial small protein modeling.Frontiers in microbiology · 2026Article
- Harnessing Machine Learning Approaches for the Identification, Characterization, and Optimization of Novel Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2025Review
- De novo origin of numerous microproteins in enterobacteria.Nucleic acids research · 2025Article
- Article
- Domoic Acid Risk and the Potential of Meta-Omics for Environmental Surveillance.Global change biology · 2025Article
- Article
- AI-Driven Antimicrobial Peptide Discovery: Mining and Generation.Accounts of chemical research · 2025Review
- Popcorn: prediction of short coding and noncoding genomic sequences in prokaryotes.Bioinformatics (Oxford, England) · 2025Article
- Structure, Function, and Regulation of LytA: TheMicroorganisms · 2025Review
- The hidden bacterial microproteome.Molecular cell · 2025Article
- Mining microbiomes for microproteins.Nature reviews. Microbiology · 2025Article
- sORFdb - a database for sORFs, small proteins, and small protein families in bacteria.BMC genomics · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Small open reading frames (smORFs) shorter than 100 codons are widespread and perform essential roles in microorganisms, where they encode proteins active in several cell functions, including signal pathways, stress response, and antibacterial activities. However, the ecology, distribution and role of small proteins in the global microbiome remain unknown. Here, we construct a global microbial smORFs catalog (GMSC) derived from 63,410 publicly available metagenomes across 75 distinct habitats and 87,920 high-quality isolate genomes. GMSC contains 965 million non-redundant smORFs with comprehensive annotations. We find that archaea harbor more smORFs proportionally than bacteria. We moreover provide a tool called GMSC-mapper to identify and annotate small proteins from microbial (meta)genomes. Overall, this publicly-available resource demonstrates the immense and underexplored diversity of small proteins.
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Registered trials
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