ArticleNature communications2024
Ultraconformable cuff implants for long-term bidirectional interfacing of peripheral nerves at sub-nerve resolutions.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- From trade-offs to translation: An interdisciplinary roadmap for neurotechnology.Science advances · 2026Review
- Neural dynamics of temporal interference stimulation monitoring by soft liquid metal interfaces across neural systems.Nature communications · 2026Article
- Surface circumferential spinal cord recording in freely moving rodents.Nature communications · 2026Article
- Seamless human electronics interfacing through advanced skin attachable and implantable sensor technologies.Discover nano · 2026Review
- Localized Tacrolimus Delivery for Peripheral Nerve Regeneration: Molecular Mechanisms, Biomaterial Platforms, and Translational Strategies.International journal of molecular sciences · 2026Review
- Micro-Texturized and Ultra-Soft Dry Electrode for Motion-Artifact Tolerant and Long-Term Stable Wearable Electrophysiological Monitoring.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Ultrathin and ultrastrong hydrogel bioelectronic membranes.National science review · 2026Article
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
- PEDOT:PSS-A Key Material for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Conformable thin-film cuff electrodes as tools for peripheral nerve recording: a comparative study.Frontiers in neuroscience · 2026Article
- Implantable bioelectronics for gut electrophysiology.Nature communications · 2025Article
- Bioadhesive and conformable bioelectronic interfaces for vasomotoricity monitoring and regulation.Nature communications · 2025Article
- A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution.Nature communications · 2025Article
- Fabrication of thin-film electrodes and organic electrochemical transistors for neural implants.Nature protocols · 2025Review
- Recent Advances in Stimuli-Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces.iScience · 2025Article
- Ultraconformable cuff implants for long-term bidirectional interfacing of peripheral nerves at sub-nerve resolutions.Nature communications · 2024Article
- Electrochemically actuated microelectrodes for minimally invasive peripheral nerve interfaces.Nature materials · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Implantable devices interfacing with peripheral nerves exhibit limited longevity and resolution. Poor nerve-electrode interface quality, invasive surgical placement and development of foreign body reaction combine to limit research and clinical application of these devices. Here, we develop cuff implants with a conformable design that achieve high-quality and stable interfacing with nerves in chronic implantation scenarios. When implanted in sensorimotor nerves of the arm in awake rats for 21 days, the devices record nerve action potentials with fascicle-specific resolution and extract from these the conduction velocity and direction of propagation. The cuffs exhibit high biocompatibility, producing lower levels of fibrotic scarring than clinically equivalent PDMS silicone cuffs. In addition to recording nerve activity, the devices are able to modulate nerve activity at sub-nerve resolution to produce a wide range of paw movements. When used in a partial nerve ligation rodent model, the cuffs identify and characterise changes in nerve C fibre activity associated with the development of neuropathic pain in freely-moving animals. The developed implantable devices represent a platform enabling new forms of fine nerve signal sensing and modulation, with applications in physiology research and closed-loop therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.