ArticleNature communications2024
Giant viruses as reservoirs of antibiotic resistance genes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genomic catalogue of giant viruses reveals expanded diversity and functional potential.Nature microbiology · 2026Article
- GiantHost: a domain-adaptive and uncertainty-aware framework for giant virus host prediction.Bioinformatics (Oxford, England) · 2026Article
- A giant virus in a small lake: characterization of a new tropical algal virus expands the geographical and genetic diversity of the Brazilian virosphere.Journal of virology · 2026Article
- Phages drive the dissemination of antibiotic resistance genes by facilitating host adaptation to heavy metal stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Antimicrobial resistance dissemination via horizontal gene transfer is constrained in stratified waters.Communications biology · 2026Article
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- Containment of antimicrobial resistance for strengthening global public health security: Biorisk management perspectives.Biosafety and health · 2026Review
- Deep-sea viral diversity and their role in host metabolism of complex organic matter.Nature communications · 2025Article
- Giant virus genomes are unlikely to be reservoirs of antibiotic resistance genes.Nature communications · 2025Article
- Reply to: Giant virus genomes are unlikely to be reservoirs of antibiotic resistance genes.Nature communications · 2025Article
- One Earth-One Health to Combat Antimicrobial Resistance Having a Dual Mutation Pattern, Based on the Robust Self-Regulation and Perpetual Reconstruction of Ecosystems.Antibiotics (Basel, Switzerland) · 2025Article
- Nano-biochar regulates phage-host interactions, reducing antibiotic resistance genes in vermicomposting systems.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- GiantHunter: accurate detection of giant virus in metagenomic data using reinforcement-learning and Monte Carlo tree search.Bioinformatics (Oxford, England) · 2025Article
- Conserved marseilleviruses harboring diverse antibiotic resistance genes isolated from the Yangtze river Delta and the Pearl river delta, China.Scientific reports · 2025Article
- AnBiochemistry and biophysics reports · 2024Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleocytoplasmic large DNA viruses (NCLDVs; also called giant viruses), constituting the phylum Nucleocytoviricota, can infect a wide range of eukaryotes and exchange genetic material with not only their hosts but also prokaryotes and phages. A few NCLDVs were reported to encode genes conferring resistance to beta‑lactam, trimethoprim, or pyrimethamine, suggesting that they are potential vehicles for the transmission of antibiotic resistance genes (ARGs) in the biome. However, the incidence of ARGs across the phylum Nucleocytoviricota, their evolutionary characteristics, their dissemination potential, and their association with virulence factors remain unexplored. Here, we systematically investigated ARGs of 1416 NCLDV genomes including those of almost all currently available cultured isolates and high-quality metagenome-assembled genomes from diverse habitats across the globe. We reveal that 39.5% of them carry ARGs, which is approximately 37 times higher than that for phage genomes. A total of 12 ARG types are encoded by NCLDVs. Phylogenies of the three most abundant NCLDV-encoded ARGs hint that NCLDVs acquire ARGs from not only eukaryotes but also prokaryotes and phages. Two NCLDV-encoded trimethoprim resistance genes are demonstrated to confer trimethoprim resistance in Escherichia coli. The presence of ARGs in NCLDV genomes is significantly correlated with mobile genetic elements and virulence factors.
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