ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Comorbidity of white matter lesions in parkinson's disease: a study on risk factors and phenotypic differences.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson's disease with cognitive impairment and their potential to predict conversion to dementia.Quantitative imaging in medicine and surgery · 2025Article
- Exploration of heterogeneity in risk factors associated with imaging subtypes of white matter hyperintensities on fluid-attenuated inversion recovery magnetic resonance imaging.Frontiers in neurology · 2025Article
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5 authors.
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Abstract
backgroundComorbidity of white matter lesions (WMLs) in idiopathic Parkinson's disease (PD) is becoming increasingly common.
objectiveTo analyze the risk factors and phenotypic differences for the occurrence and severity of WMLs in patients with PD.
methodsA total of 123 PD patients underwent clinical, laboratory, and magnetic resonance imaging (MRI) evaluations.
resultsPD patients with WMLs were found to have a higher association with age, Modified Hoehn & Yahr stage (H-Y stage), and hypertension. There was a certain correlation between the severity of WMLs and PD phenotypes. 89% of PD patients had periventricular hyperintensities (PVH). Additionally, the score of the modified version of the Scheltens visual rating scale of PVH in the postural instability gait difficulty (PIGD) phenotype of PD was significantly higher than that in the tremor-dominant (TD) phenotype. The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in the PIGD group were significantly lower than those in the TD group. Furthermore, compared with the TD group, the serum homocysteine level was significantly higher in the PIGD group.
conclusionsAge, H-Y stage, and hypertension are independent risk factors for WMLs in PD, and the severity of WMLs is related to the phenotype of PD patients. Our study found that PVH is the most common occurrence of WMLs in Parkinson's disease, and the burden of PVH is significantly higher in the PIGD phenotype compared to the TD phenotype of PD. Additionally, the PIGD phenotype is associated with more severe cognitive decline and elevated homocysteine levels.
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