Evidence map›Paper›PMID 39214703›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Brief and Diverse Excitotoxic Insults Increase the Neuronal Nuclear Membrane Permeability in the Neonatal Brain, Resulting in Neuronal Dysfunction and Cell Death.

Pratyush Suryavanshi, Rachel Langton, Kimberly Fairhead, Joseph Glykys

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Pratyush SuryavanshiDepartment of Pediatrics, The University of Iowa, Iowa City, Iowa 52242.ORCID 0000-0001-6904-7294
Rachel LangtonDepartment of Pediatrics, The University of Iowa, Iowa City, Iowa 52242.
Kimberly FairheadBiomedical Sciences, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, Iowa 52242.
Joseph GlykysDepartment of Pediatrics, The University of Iowa, Iowa City, Iowa 52242 joseph-glykys@uiowa.edu.ORCID 0000-0002-1499-9172

Funding

University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI Lane Strathearn · 2021 to 2026
$8.5M
Water and chloride movement in neurons during seizure activityR01NS115800 · NINDS · UNIVERSITY OF IOWA · PI GLYKYS, JOSEPH C. · 2020 to 2024
$2.1M
NICHD NIH HHS P50 HD103556NINDS NIH HHS R01 NS115800
6 · The paper itself

Abstract

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca

Indexed as

Animals, NewbornCell DeathNeuronsAnimalsBrainBrain EdemaCalciumFemaleMaleMiceMice, Inbred C57BLNuclear EnvelopeCalciumapoptosiscell deathcytotoxic edemanuclear dysregulationOGDseizures

Identifiers

PMID39214703
PMCPMC11466074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.