Evidence map›Paper›PMID 39214637›Full record

SynthesisThe Lancet. Public health2024

Interventions to reduce harms related to drug use among people who experience incarceration: systematic review and meta-analysis.

Christel Macdonald, Georgina Macpherson, Oscar Leppan, Lucy Thi Tran, Evan B Cunningham, Behzad Hajarizadeh, Jason Grebely, Michael Farrell, Frederick L Altice, Louisa Degenhardt

Erratum issuedAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The Lancet. Public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. EuroHePP: The European Toolkit to Strengthen National Responses for the Elimination of Viral Hepatitis in Prisons.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. A self-assessment of opioid use disorder services at a Pacific Northwest County jail.Substance abuse treatment, prevention, and policy · 2025
    Article
  9. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. The burden of drug overdose deaths among correctional populations: implications for interventions.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Christel MacdonaldNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Georgina MacphersonNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Oscar LeppanNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Lucy Thi TranNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Evan B CunninghamThe Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Behzad HajarizadehThe Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Jason GrebelyThe Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Michael FarrellNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Frederick L AlticeYale School of Medicine and School of Public Health, New Haven, CT, USA.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia. Electronic address: l.degenhardt@unsw.edu.au.

Funding

Prison Interventions and HIV Prevention CollaborationR01DA029910 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE · 2010 to 2026
$7.9M
Expanding Medication Assisted Therapy in Ukraine (ExMAT)R01DA033679 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2012 to 2021
$6.4M
Integrating Addiction Treatment and HIV Services into Primary Care Clinics in UkraineR01DA043125 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2016 to 2021
$4.4M
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice SettingsR01DA041271 · NIDA · YALE UNIVERSITY · PI SHENOI, SHEELA · 2016 to 2021
$3.3M
Innovations in Implementing Decentralized HIV Services in PeruR01AI177082 · NIAID · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE · 2023 to 2026
$2.8M
TRANSFORM - Transforming the evidence base on estimating prevalence of opioid use disorder and expanded access to interventions to prevent drug related deaths: an international data linkage studyR01DA059822 · NIDA · UNIVERSITY OF NEW SOUTH WALES · PI Joshua Adam Barocas, Louisa Degenhardt · 2024 to 2026
$2.3M
Malaysian Implementation Science Training (MIST) Program in HIVD43TW011324 · FIC · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE, Rafdzah Zaki · 2020 to 2026
$1.8M
Identifying Challenges and Opportunities for PrEP Uptake Among Women at Elevated HIV Risk in GeorgiaD43TW012492 · FIC · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE, Denise Esserman · 2023 to 2026
$1.3M
Reducing Stigma in People Who Inject Drugs with HIV Using a Rapid Start Antiretroviral Therapy InterventionR01TW012674 · FIC · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2023 to 2025
$710k
FIC NIH HHS D43 TW011324FIC NIH HHS D43 TW012492FIC NIH HHS R01 TW012674NIAID NIH HHS R01 AI177082NIDA NIH HHS R01 DA029910NIDA NIH HHS R01 DA033679NIDA NIH HHS R01 DA041271NIDA NIH HHS R01 DA043125NIDA NIH HHS R01 DA059822
6 · The paper itself

Abstract

backgroundMortality, suicide, self-harm, and substance use are elevated among people who are incarcerated. There is a wide range of heterogeneous interventions aimed at reducing these harms in this population. Previous reviews have focused on specific interventions or limited their findings to drug use and recidivism and have not explored interventions delivered after release from prison. Our aim is to examine the effect of interventions delivered to people who use drugs during incarceration or after release from incarceration, on a wide range of outcomes.

methodsIn this systematic review and meta-analysis, we searched Embase, MEDLINE, and PsycINFO databases up until Sept 12, 2023 for studies published from Jan 1, 1980 onwards. All studies evaluating the effectiveness of any intervention on drug use, recidivism outcomes, sexual or injecting risk behaviours, or mortality among people who use psychoactive drugs and who were currently or recently incarcerated were included. Studies without a comparator or measuring only alcohol use were excluded. Data extracted from each study included demographic characteristics, interventions, and comparisons. Pooled odds ratios and risk ratios were calculated using random-effects meta-analyses.

findingsWe identified 126 eligible studies (47 randomised controlled trials and 79 observational studies) encompassing 18 interventions; receiving opioid-agonist treatment (OAT) in prison reduced the risk of death in prison (one study; hazard ratio 0·25; 95% CI 0·13-0·48), whereas receiving OAT in the first 4 weeks following release reduced risk of death in the community (two studies; relative risk 0·24; 95% CI 0·15-0·37). Therapeutic community interventions reduced re-arrest at 6-12 months (six studies; odds ratio [OR] 0·72; 95% CI 0·55-0·95) and reincarceration at 24 months (two studies; OR 0·66; 95% CI 0·48-0·96). There was scarce evidence that OAT and syringe service provision are effective in reducing injecting risk behaviours and needle and syringe sharing.

interpretationThere are effective interventions to reduce mortality and recidivism for people who use drugs who have been incarcerated. Nonetheless, there are also substantial gaps in the research examining the effect of interventions on risk behaviours and mortality during incarceration and a need for randomised designs examining outcomes for people who use drugs after release.

fundingAustralian National Health and Medical Research Council.

Indexed as

PrisonersSubstance-Related DisordersHarm ReductionHumansIncarceration

Identifiers

PMID39214637
PMCPMC11996259

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.