ArticleCell host & microbe2024
Bacteroides ovatus alleviates dysbiotic microbiota-induced graft-versus-host disease.
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Article in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- 15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial.Nature medicine · 2026Trial
- Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect.Nature communications · 2025Trial
- The gut microbiome in graft-versus-host disease: mechanisms of immune modulation and therapeutic approaches.Gut microbes · 2026Review
- The gut microbiota and host immunity synergistically orchestrate colonization resistance.Gut microbes · 2026Review
- The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation.American journal of hematology · 2026Review
- Dietary Fiber from Baijiu Distillers' Grains Improves Glucose-Lipid Homeostasis via Gut-Liver Metabolic Remodeling.Foods (Basel, Switzerland) · 2026Article
- The gut microbiome in solid-organ and haematopoietic-stem-cell transplantation.Nature reviews. Microbiology · 2026Review
- The intestinal microbiota as a key modulator of acute graft-versus-host disease.Nature reviews. Cancer · 2026Review
- Fecal carbohydrate-degrading bacteria are associated with reduced incidence of lower gastrointestinal GVHD.Blood advances · 2026Article
- Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.NPJ Parkinson's disease · 2026Article
- Bacteroides ovatus Has the Potential to Be a Next-Generation Probiotic Strain.Probiotics and antimicrobial proteins · 2026Review
- Gut microbiome components predict response to neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy in locally advanced rectal cancer (UNION): a prospective study.Frontiers in pharmacology · 2026Article
- Reduced gut microbial diversity characterized by decreasedFrontiers in cellular and infection microbiology · 2026Observational
- Gastrointestinal acute graft versus host disease: a translational perspective from pathogenesis to precision prevention and treatment.Frontiers in immunology · 2026Review
- A Distinct Intestinal Domination Fingerprint in Patients Undergoing Allo-HSCT: Dynamics, Predictors and Implications on Clinical Outcomes.Journal of clinical medicine · 2025Article
- Enterococcus proliferates via the phosphotransferase system in the disrupted gut microbiota after allogeneic haematopoietic stem cell transplantation.British journal of haematology · 2025Article
- Gut microbiota and acute graft-versus-host disease.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Timing and Protocols for Microbiome Intervention in Surgical Patients: A Literature Review of Current Evidence.Cureus · 2025Review
- Levofloxacin Prophylaxis in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation Recipients Does not Prevent Infective Complications and Infections-related Deaths.Open forum infectious diseases · 2025Article
- Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure.Biochemistry · 2025Article
Corrections and comments
- Update of
Authors and funding
55 authors.
Eiko HayaseDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: ekhayase@gmail.com.
Tomo HayaseDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Akash MukherjeeDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Stuart C StinsonDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mohamed A JamalDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Miriam R OrtegaDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Christopher A SanchezDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Saira S AhmedDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Jennifer L KarmouchDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Chia-Chi ChangDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Ivonne I FloresDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Lauren K McDanielDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Alexandria N BrownDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Rawan K El-HimriDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Valerie A ChapaDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Lin TanMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
Bao Q TranMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
Yao XiaoDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Christopher FanDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Dung PhamDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Taylor M HalseyDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Yimei JinDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Wen-Bin TsaiDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Rishika PrasadDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Israel K GloverDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Altai EnkhbayarDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Aqsa MohammedDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Maren SchmiesterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Katherine Y KingCenter for Cell and Gene Therapy and Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
Robert A BrittonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Pavan ReddyDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Matthew C WongDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Nadim J AjamiDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Jennifer A WargoDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Samuel ShelburneDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Pablo C OkhuysenDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Chen LiuDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Stephanie W FowlerDepartment of Molecular Virology and Microbiology and Department of Education, Innovation, and Technology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Comparative Medicine and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Margaret E ConnerDepartment of Molecular Virology and Microbiology and Department of Education, Innovation, and Technology, Baylor College of Medicine, Houston, TX 77030, USA.
Zoe KatsamakisAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Natalie SmithAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Marina Burgos da SilvaAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Doris M PonceAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jonathan U PeledAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10021, USA.
Marcel R M van den BrinkAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10021, USA.
Christine B PetersonDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Gabriela RondonDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jeffrey J MolldremDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Richard E ChamplinDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Elizabeth J ShpallDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Philip L LorenziMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
Rohtesh S MehtaDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Eric C MartensDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Amin M AlousiDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Robert R JenqDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; CPRIT Scholar in Cancer Research, Houston, TX, USA. Electronic address: rjenq@coh.org.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3MMucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantationP01HL170046 · NHLBI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Robert Jenq · 2024 to 2026
$9.8MProtecting colonic mucus to mitigate acute intestinal graft-versus-host diseaseR01HL124112 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JENQ, ROBERT · 2015 to 2024
$6.8MImpact of Infection and Inflammation on Primitive HematopoiesisR35HL155672 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Katherine Yudeh King · 2021 to 2026
$5.1MNew data science approaches to visualize and understand the impact of the microbiome on risk of graft-versus-host diseaseR01HL158796 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PETERSON, CHRISTINE B · 2022 to 2025
$1.0MMicrobiota mechanisms and biomarkers in GVHDK08HL143189 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI PELED, JONATHAN · 2019 to 2023
$858kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016672NHLBI NIH HHS K08 HL143189NHLBI NIH HHS P01 HL170046NHLBI NIH HHS R01 HL124112NHLBI NIH HHS R01 HL158796NHLBI NIH HHS R35 HL155672NIDDK NIH HHS P30 DK056338
Abstract
Acute lower gastrointestinal GVHD (aLGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation. Although the intestinal microbiota is associated with the incidence of aLGI-GVHD, how the intestinal microbiota impacts treatment responses in aLGI-GVHD has not been thoroughly studied. In a cohort of patients with aLGI-GVHD (n = 37), we found that non-response to standard therapy with corticosteroids was associated with prior treatment with carbapenem antibiotics and a disrupted fecal microbiome characterized by reduced abundances of Bacteroides ovatus. In a murine GVHD model aggravated by carbapenem antibiotics, introducing B. ovatus reduced GVHD severity and improved survival. These beneficial effects of Bacteroides ovatus were linked to its ability to metabolize dietary polysaccharides into monosaccharides, which suppressed the mucus-degrading capabilities of colonic mucus degraders such as Bacteroides thetaiotaomicron and Akkermansia muciniphila, thus reducing GVHD-related mortality. Collectively, these findings reveal the importance of microbiota in aLGI-GVHD and therapeutic potential of B. ovatus.
Indexed as
BacteroidesGastrointestinal MicrobiomeGraft vs Host DiseaseAdultAkkermansiaAnimalsBacteroides thetaiotaomicronDisease Models, AnimalDysbiosisFecesFemaleHematopoietic Stem Cell TransplantationHumansMaleMiceMice, Inbred BALB CAkkermansia muciniphilaallogeneic hematopoietic stem cell transplantationBacteroides ovatusBacteroides thetaiotaomicrongraft-versus-host diseaseintestinal microbiomemucus layerpolysaccharidespolysaccharide utilization locixylose
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.