Evidence map›Paper›PMID 39213738›Full record

Trial reportBehaviour research and therapy2024

A parallel-arm, randomized trial of Behavioral Activation Therapy for anhedonia versus mindfulness-based cognitive therapy for adults with anhedonia.

Paul M Cernasov, Erin C Walsh, Gabriela A Nagy, Jessica L Kinard, Lisalynn Kelley, Rachel D Phillips, Angela Pisoni, Joseph Diehl, Kevin Haworth, Jessica West and 7 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Behaviour research and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02874534 nacompletednot on this map

Development of a Novel Transdiagnostic Intervention for Anhedonia - R61 Phase

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2017 to 2019Enrolled57ConditionsAnhedoniaArmsBehavioral Activation, Mindfulness Treatment
NCT04036136 nacompletednot on this map

Development of a Novel Transdiagnostic Intervention for Anhedonia - R33 Phase

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2023Enrolled116ConditionsAnhedoniaArmsBehavioral Activation, Mindfulness Treatment
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Anhedonia: Current and future treatments.PCN reports : psychiatry and clinical neurosciences · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Paul M CernasovDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: paul.cernasov@unc.edu.
Erin C WalshDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Gabriela A NagyDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA; Duke University School of Nursing, Durham, NC, USA.
Jessica L KinardCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Division of Speech and Hearing Sciences, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Lisalynn KelleyDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Rachel D PhillipsDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Angela PisoniDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Joseph DiehlDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Kevin HaworthDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Jessica WestDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Louise FreemanDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Courtney PfisterDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
McRae ScottDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stacey B DaughtersDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Susan GaylordDepartment of Physical Medicine and Rehabilitation, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Gabriel S DichterDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Moria J SmoskiDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.

Funding

North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Development of A Novel Transdiagnostic Intervention for AnhedoniaR33MH110027 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DICHTER, GABRIEL S, SMOSKI, MORIA J. · 2019 to 2021
$2.3M
Development of A Novel Transdiagnostic Intervention for AnhedoniaR61MH110027 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DICHTER, GABRIEL S, SMOSKI, MORIA J. · 2017 to 2018
$1.9M
Neuroinflammatory Mechanisms of Anhedonia in Major DepressionK23MH113733 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WALSH, ERIN · 2018 to 2023
$866k
NCATS NIH HHS UM1 TR004406NICHD NIH HHS P50 HD103573NIMH NIH HHS K23 MH113733NIMH NIH HHS R33 MH110027NIMH NIH HHS R61 MH110027
6 · The paper itself

Abstract

backgroundAnhedonia, deficits in motivation and pleasure, is a transdiagnostic symptom of psychopathology and negative prognostic marker.

methodsIn this randomized, parallel-arm clinical trial, a novel intervention, Behavioral Activation Treatment for Anhedonia (BATA), was compared to an individually administered Mindfulness-Based Cognitive Therapy (MBCT) in a transdiagnostic cohort of adults with clinically significant anhedonia (ClinicalTrials.gov Identifiers NCT02874534 and NCT04036136). Participants received 8-15 individual psychotherapy sessions, once weekly, with either BATA (n = 61) or MBCT (n = 55) and completed repeated self-report assessment of anhedonia and other internalizing symptoms.

resultsIndicators of treatment feasibility were similar across conditions, though MBCT showed a trend towards greater attrition rates than BATA, with an adjusted odd's ratio of 2.04 [0.88, 4.73]. Treatment effects on the primary clinical endpoint of anhedonia symptoms did not significantly differ, with a 14-week estimated difference on the Snaith Hamilton Pleasure Scale (SHAPS) of -0.20 [-2.25, 1.84] points in BATA compared to MBCT (z = 0.19, p = 0.845, d = 0.05). The expected 14-week change in SHAPS scores across conditions was -7.18 [-8.22, -6.15] points (z = 13.6, p < 0.001, d = 1.69). There were no significant differences in the proportion of participants demonstrating reliable and clinically significant improvements in SHAPS scores, or in the magnitude of internalizing symptom reductions. LIMITATIONS: Limitations included a modest sample size, lack of longer-term follow up data, and non-preregistered analytic plan. DISCUSSION: There was no evidence to support superior clinical efficacy of BATA over MBCT in a transdiagnostic cohort of adults with elevated anhedonia. Both interventions reduced anhedonia symptoms to a comparable magnitude of other existing treatments.

Indexed as

AnhedoniaCognitive Behavioral TherapyMindfulnessAdultBehavior TherapyFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultAnhedoniaBehavioral activationMindfulnessSHAPS

Identifiers

PMID39213738
PMCPMC11519751

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.