Evidence map›Paper›PMID 39213065›Full record

Observational studyJournal of Alzheimer's disease : JAD2024

A Comparison of an Australian Observational Longitudinal Alzheimer's Disease Cohort to Community-Based Australian Data.

Andrew Liem Hieu Huynh, Yihan Wang, Liwei Ma, Yi Ling Clare Low, Weisi Chen, Christopher Fowler, Edwin C K Tan, Colin L Masters, Liang Jin, Yijun Pan and 1 more

Abstract readComparative StudyObservational Study
In one paragraph

Observational study in Journal of Alzheimer's disease : JAD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrew Liem Hieu HuynhThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Yihan WangThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Liwei MaThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Yi Ling Clare LowThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Weisi ChenSchool of Pharmacy, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
Christopher FowlerThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Edwin C K TanSchool of Pharmacy, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
Colin L MastersThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Liang JinThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Yijun PanThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
AIBL Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Observational Alzheimer's disease (AD) cohorts including the Australian, Biomarkers, Imaging and Lifestyle (AIBL) Study have enhanced our understanding of AD. The generalizability of findings from AIBL to the general population has yet to be studied. Objective: We aimed to compare characteristics of people with AD dementia in AIBL to 1) the general population of older Australians using pharmacological treatment for AD dementia, and to 2) the general population of older Australians who self-reported a diagnosis of dementia. Methods: Descriptive study comparing people aged 65 years of over (1) in AIBL that had a diagnosis of AD dementia, (2) dispensed with pharmacological treatment for AD in Australia in 2021 linked to the Australian census in 2021 (refer to as PBS/census), (3) self-reported a diagnosis of dementia in the 2021 Australian census (refer to as dementia/census). Baseline characteristics included age, sex, highest education attainment, primary language, and medical co-morbidities. Results: Participants in AIBL were younger, had more years of education, and had a lower culturally and linguistically diverse (CALD) population compared to the PBS/census cohort and dementia/census cohort (mean age±standard deviation - AIBL 79±7 years, PBS/census 81±7, p < 0.001, dementia/census 83±8, p < 0.001; greater than 12 years of education AIBL 40%, PBS/census 35%, p = 0.020, dementia/census 29%, p < 0.001; CALD - AIBL 3%, PBS/census 20%, p < 0.001, dementia/census 22%, p < 0.001). Conclusions: Our findings suggest that care should be taken regarding the generalizability of AIBL in CALD populations and the interpretation of results on the natural history of AD.

Indexed as

Alzheimer DiseaseAgedAged, 80 and overAustraliaCohort StudiesFemaleHumansLongitudinal StudiesMaleAlzheimer’s diseaseAustralian Biomarkers Imaging and Lifestyle studyAustralian censusculturally and linguistically diversedementiageneralizability

Identifiers

PMID39213065
PMCPMC11491991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.