Evidence map›Paper›PMID 39212863›Full record

ReviewHepatology international2024

Diagnosis and management of pediatric acute liver failure: consensus recommendations of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN).

Bikrant Bihari Lal, Rajeev Khanna, Vikrant Sood, Seema Alam, Aabha Nagral, Aathira Ravindranath, Aditi Kumar, Akash Deep, Amrit Gopan, Anshu Srivastava and 33 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Hepatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Therapeutic plasma exchange in hepatitis A-related acute liver failure: Does study design influence interpretation?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
  5. Review
  6. Article
  7. Clinical, economic and social impact of hepatitis A virus: Impact of gastrointestinal co-infections on disease course.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Plasma exchange to treat liver failure: The field expands.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Article
  12. Harnessing the UDP-G/P2YActa pharmaceutica Sinica. B · 2025
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Bikrant Bihari LalDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.
Rajeev KhannaDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.
Vikrant SoodDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.
Seema AlamDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India. seema_alam@hotmail.com.ORCID http://orcid.org/0000-0003-0888-8625
Aabha NagralDepartment of Gastroenterology, Jaslok Hospital and Research Center, Mumbai, India.
Aathira RavindranathDepartment of Pediatric Gastroenterology, Apollo BGS Hospital, Mysuru, Karnataka, India.
Aditi KumarDepartment of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, India.
Akash DeepDepartment of Pediatric Intensive Care, King's College Hospital, London, UK.
Amrit GopanDepartment of Pediatric Gastroenterology and Hepatology, Sir H.N Reliance Foundation Hospital, Mumbai, India.
Anshu SrivastavaDepartment of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Arjun MariaDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India.
Arti PawariaDepartment of Pediatric Hepatology and Gastroenterology, Amrita Institute of Medical Sciences, Faridabad, India.
Ashish BavdekarDepartment of Pediatrics, KEM Hospital and Research Centre, Pune, India.
Gaurav SindwaniDepartment of Organ Transplant Anesthesia and Critical Care, Institute of Liver and Biliary Sciences, New Delhi, India.
Kalpana PandaDepartment of Pediatrics, Institute of Medical Sciences & SUM Hospital, Bhubaneshwar, India.
Karunesh KumarDepartment of Pediatric Gastroenterology and Liver Transplantation, Indraprastha Apollo Hospitals, New Delhi, India.
Malathi SathiyasekaranDepartment of Paediatric Gastroenterology, Rainbow Children's Hospital, Chennai, India.
Maninder DhaliwalDepartment of Pediatric Intensive Care, Amrita Institute of Medical Sciences, Faridabad, India.
Marianne SamynDepartment of Pediatric Hepatology, King's College Hospital, London, UK.
Maya PeethambaranDepartment of Pediatric Gastroenterology and Hepatology, VPS Lakeshore Hospital, Kochi, Kerala, India.
Moinak Sen SarmaDepartment of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Moreshwar S DesaiDepartment of Paediatric Critical Care and Liver ICU, Baylor College of Medicine &Texas Children's Hospital, Houston, TX, USA.
Neelam MohanDepartment of Pediatric Gastroenterology and Hepatology, Medanta the Medicity Hospital, Gurugram, India.
Nirmala DheivamaniDepartment of Paediatric Gastroenterology, Institute of Child Health and Hospital for Children, Egmore, Chennai, India.
Piyush UpadhyayDepartment of Pediatrics, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Pratibha KaleDepartment of Microbiology, Institute of Liver and Biliary Sciences, New Delhi, India.
Rakhi MaiwallDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Rohan MalikDepartment of Pediatric Gastroenterology and Hepatology, All India Institute of Medical Sciences, New Delhi, India.
Roshan Lal KoulDepartment of Neurology, Institute of Liver and Biliary Sciences, New Delhi, India.
Snehavardhan PandeyDepartment of Pediatric Hepatology and Liver Transplantation, Sahyadri Superspeciality Hospital Pvt Ltd Pune, Pune, India.
Somashekara Hosaagrahara RamakrishnaDepartment of Pediatric Hepatology and Liver Transplantation, Glenegales Global Health City, Chennai, India.
Surender Kumar YachhaDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplantation, Sakra World Hospital, Bangalore, India.
Sadhna LalDivision of Pediatric Gastroenterology and Hepatology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Sahana ShankarDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Mazumdar Shaw Medical Centre, Narayana Health City, Bangalore, India.
Sajan AgarwalDepartment of Pediatric Gastroenterology and Hepatology, Gujarat Gastro Hospital, Surat, Gujarat, India.
Shivani DeswalDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplant, Narayana Health, DLF Phase 3, Gurugram, India.
Smita MalhotraDepartment of Pediatric Gastroenterology and Hepatology, Indraprastha Apollo Hospitals, New Delhi, India.
Vibhor BorkarDepartment of Paediatric Hepatology and Gastroenterology, Nanavati Max Super Speciality Hospital, Mumbai, Maharashtra, India.
Vipul GautamDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplantation, Max Superspeciality Hospital, New Delhi, India.
Viswanathan M SivaramakrishnanDepartment of Paediatric Gastroenterology and Hepatology, Apollo Children's Hospital, Chennai, India.
Anil DhawanDepartment of Pediatric Hepatology, King's College Hospital, London, UK.
Mohamed RelaDepartment of Liver Transplantation and HPB (Hepato-Pancreatico-Biliary) Surgery, Dr. Rela Institute & Medical Center, Chennai, India.
Shiv Kumar SarinDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Timely diagnosis and management of pediatric acute liver failure (PALF) is of paramount importance to improve survival. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition invited national and international experts to identify and review important management and research questions. These covered the definition, age appropriate stepwise workup for the etiology, non-invasive diagnosis and management of cerebral edema, prognostic scores, criteria for listing for liver transplantation (LT) and bridging therapies in PALF. Statements and recommendations based on evidences assessed using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) system were developed, deliberated and critically reappraised by circulation. The final consensus recommendations along with relevant published background information are presented here. We expect that these recommendations would be followed by the pediatric and adult medical fraternity to improve the outcomes of PALF patients.

Indexed as

GastroenterologyLiver Failure, AcuteLiver TransplantationBrain EdemaChildHumansIndiaPrognosisSocieties, MedicalAcute liver failureBridging therapiesContinuous renal replacement therapyDiagnosisGuidelinesLiver transplantationManagementMolecular adsorbent recirculating systemNon-invasive assessment of cerebral edemaPediatric acute liver failureTherapeutic plasma exchange

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.