Evidence map›Paper›PMID 39212733›Full record

ArticleCellular and molecular life sciences : CMLS2024

Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation.

Rongzhen Li, Xiaobing Huang, Linjing Shen, Tianjiao Zhang, Ning Liu, Xiangqing Hou, Garry Wong

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rongzhen LiCancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, E12-3005 Avenida da Universidade, Macau, 999078, China.
Xiaobing HuangCancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, E12-3005 Avenida da Universidade, Macau, 999078, China.
Linjing ShenCancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, E12-3005 Avenida da Universidade, Macau, 999078, China.
Tianjiao ZhangCancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, E12-3005 Avenida da Universidade, Macau, 999078, China.
Ning LiuCancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, E12-3005 Avenida da Universidade, Macau, 999078, China.
Xiangqing HouCancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, E12-3005 Avenida da Universidade, Macau, 999078, China.
Garry WongCancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, E12-3005 Avenida da Universidade, Macau, 999078, China. GarryGWong@um.edu.mo.ORCID http://orcid.org/0000-0003-4566-9958

Funding

Research Services and Knowledge Transfer Office, University of Macau MYRG2020-00213-FHS
6 · The paper itself

Abstract

Lewy body diseases (LBD) comprise a group of complex neurodegenerative conditions originating from accumulation of misfolded alpha-synuclein (α-syn) in the form of Lewy bodies. LBD pathologies are characterized by α-syn deposition in association with other proteins such as Amyloid β (Aβ), Tau, and TAR-DNA-binding protein. To investigate the complex interactions of these proteins, we constructed 2 novel transgenic overexpressing (OE) C. elegans strains (α-syn

Indexed as

alpha-SynucleinAmyloid beta-PeptidesAnimals, Genetically ModifiedCaenorhabditis elegansDisease Models, AnimalLewy Body DiseaseMicroRNAsAnimalsCaenorhabditis elegans ProteinsDopaminergic NeuronsHumanstau Proteinsalpha-SynucleinAmyloid beta-PeptidesCaenorhabditis elegans ProteinsMicroRNAstau ProteinsAmyloid βParkinson’s diseaseTAR-DNA-binding protein 43Tau proteinα-Synuclein

Identifiers

PMID39212733
PMCPMC11364739

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.