Evidence map›Paper›PMID 39212702›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Alterations of gut microbiome in eosinophilic chronic rhinosinusitis.

Yibo Liang, Chenting Zhang, Xin Xiong, Xiang Mao, Peiyong Sun, Zhenzhong Yue, Wei Wang, Runxiang Xie, Guimin Zhang

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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yibo LiangDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
Chenting ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
Xin XiongDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
Xiang MaoDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
Peiyong SunDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
Zhenzhong YueDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
Wei WangDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
Runxiang XieDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, 59 Liu Ting Street, Haishu District, Ningbo, 315000, Zhejiang, China. xierunxiang@tmu.edu.cn.
Guimin ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China. zh_gm@163.com.ORCID http://orcid.org/0000-0001-9042-4015

Funding

Natural Science Foundation of Tianjin Municipality 19JCYBJC27200Tianjin Municipal Health Commission TJWJ2022XK020
6 · The paper itself

Abstract

purposeA growing body of evidence has elucidated that the gut microbiota has a crucial impact on the pathophysiological process of atopic diseases. Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is a local atopic disease of the systemic immune response. Alterations in the gut microbiome in eCRSwNP patients remain largely undefined.

methods16S rRNA gene sequencing was performed in a cross-sectional study of 17 eCRSwNP patients, 9 noneCRSwNP patients and 13 healthy controls, and gut microbiota DNA sequencing between each pair of groups was compared using bioinformatic methods.

resultsCompared with that of healthy controls, the gut microbiomes of eCRSwNP patients were characterised by a distinct overall microbial composition. However, no significant differences were found in the alpha diversity of the gut microbiota between patients and healthy controls. The distinct differences in microbial composition were significantly correlated with the severity of disease. At the genus level, the abundance of Faecalibacterium positively correlated with Lund-Mackay CT scores. Similarly, the abundance of Turicibacter positively correlated with the percentage of tissue eosinophils.

conclusionsWe found alterations in the gut microbiome in eCRSwNP patients, and the alterations in the gut microbiome were correlated with the severity of disease.

Indexed as

EosinophiliaGastrointestinal MicrobiomeRhinitisRNA, Ribosomal, 16SSinusitisAdultCase-Control StudiesChronic DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedNasal PolypsRhinosinusitisRNA, Ribosomal, 16SChronic rhinosinusitisEosinophilic chronic rhinosinusitis with nasal polypsGut microbiota

Identifiers

PMID39212702
PMCPMC11564334

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.