ArticleJournal of the National Cancer Institute2025
Plant-based diet and survival among patients with metastatic colorectal cancer.
Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Obesity, survival, and chemotherapy outcomes in stage IV colorectal cancer: a retrospective study.BMC cancer · 2026Article
- Oncologists Knowledge and Attitudes Towards Providing Dietary Guidance to Patients With Cancer.American journal of lifestyle medicine · 2026Article
- Residential Fast-Food Exposures, Colorectal Cancer-Specific, and All-Cause Mortality: A Retrospective Study of CRC Cases from the Kentucky Cancer Registry.Nutrition and cancer · 2026Article
- Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.Neoplasia (New York, N.Y.) · 2025Article
- Food as medicine in gastrointestinal cancer therapy.Nature reviews. Gastroenterology & hepatology · 2025Article
- Beyond biologics: fungal polysaccharides as dual-function materials for nanomedicine.Nanomedicine (London, England) · 2025Review
- Quality of plant-based diets in relation to all-cause and cardiovascular disease mortality in US adults with sarcopenia: a population-based study.Aging clinical and experimental research · 2025Observational
- Plant-based diet, inflammation biomarkers and body composition among women with breast cancer: the Pathways Study.The British journal of nutrition · 2025Article
- Global burden of disease for colorectal cancer due to diet low in whole grains from 1990 to 2021 and its projections to 2050: analysis of the global burden of disease study 2021.Frontiers in nutrition · 2025Article
- Global burden and projection of colorectal cancer attributable to low whole-grain diets: an analysis of GBD 2021 data with Bayesian age-period-cohort modeling.Frontiers in oncology · 2025Article
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13 authors.
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Abstract
backgroundA plant-based diet is associated with better survival among patients with nonmetastatic colorectal cancer (CRC), but its association in metastatic CRC is unknown.
methodsUsing an National Cancer Institute-sponsored trial (CALGB/SWOG 80405), we included 1284 patients who completed validated food frequency questionnaires at the initiation of metastatic CRC treatment. We calculated 3 indices: overall plant-based diet index (PDI), which emphasized consumption of all plant foods while reducing animal food intake; healthful plant-based diet index (hPDI), which emphasized consumption of healthful plant foods such as whole grains, fruits, and vegetables; and unhealthful plant-based diet index (uPDI), which emphasized consumption of less healthful plant foods such as fruit juices, refined grains, and sugar-sweetened beverages. We estimated the associations of 3 indices (quintiles) with overall survival (OS) and progression-free survival (PFS) using multivariable Cox proportional hazards regression.
resultsWe observed 1100 deaths and 1204 progression events (median follow-up = 6.1 years). Compared with the lowest quintile, patients in the highest quintile of PDI had significantly better survival (hazard ratio [HR] for OS = 0.76 [0.62-0.94], Ptrend = .004; PFS = 0.81 [0.66-0.99], Ptrend = .09). Similar findings were observed for hPDI (HR for OS = 0.81 [0.65-1.01], Ptrend = .053; PFS = 0.80 [0.65-0.98], Ptrend = .04), whereas uPDI was not associated with worse survival (HR for OS = 1.16 [0.94-1.43], Ptrend = .21; PFS = 1.12 [0.92-1.36], Ptrend = .42).
conclusionsOur study suggests that a plant-based diet, especially when rich in healthful plant foods, is associated with better survival among patients with metastatic CRC. The cause of survival benefits warrants further investigation.
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