Evidence map›Paper›PMID 39212529›Full record

ArticleParasite (Paris, France)2024

Proliferation of MDSCs may indicate a lower

Bo Peng, Yulin Luo, Shudong Xie, Quan Zhuang, Junhui Li, Pengpeng Zhang, Kai Liu, Yu Zhang, Chen Zhou, Chen Guo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasite (Paris, France), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. T cell exhaustion in parasitic infections.Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bo PengTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.ORCID 0000-0003-4482-2885
Yulin LuoTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Shudong XieTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Quan ZhuangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Junhui LiTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Pengpeng ZhangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Kai LiuTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Yu ZhangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Chen ZhouTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Chen GuoTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Zhaoqin ZhouTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Jie ZhouSchistosomiasis Control Institute of Hunan Province, Yueyang, Hunan, China - Xiangyue Hospital affiliated to Hunan Institute of Schistosomiasis Control, Yueyang, Hunan, China.
Yu CaiXiangyue Hospital affiliated to Hunan Institute of Schistosomiasis Control, Yueyang, Hunan, China.
Meng XiaXiangyue Hospital affiliated to Hunan Institute of Schistosomiasis Control, Yueyang, Hunan, China.
Ke ChengTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.
Yingzi MingTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China - NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha, Hunan, China.ORCID 0009-0009-8878-3831

Funding

Key Research and Development Program of Hunan Province of China 2021SK2032National Natural Science Foundation of China 81771722Natural Science Foundation of Hunan Province 2020JJ5863
6 · The paper itself

Abstract

backgroundSchistosoma japonicum (S. japonicum) is the main species of Schistosoma prevalent in China. Myeloid-derived suppressor cells (MDSCs) are important immunoregulatory cells and generally expand in parasite infection, but there is little research relating to MDSCs in Schistosoma infection.

methodsFifty-six S. japonicum-infected patients were included in this study. MDSCs and percentages and absolute cell numbers of lymphocyte subsets, including

resultsPatients infected with S. japonicum had a much higher percentage of MDSCs among peripheral blood mononuclear cells (PBMCs) than the healthy control. Regarding subpopulations of MDSCs, the percentage of granulocytic myeloid-derived suppressor cells (G-MDSCs) was clearly increased. Correlation analysis showed that the absolute cell counts of T-cell subsets correlated negatively with the percentages of MDSCs and G-MDSCs among PBMCs. The percentage of G-MDSCs in PBMCs was also significantly higher in patients with liver fibrosis diagnosed by color doppler ultrasound (grade > 0), and the percentage of G-MDSCs in PBMCs and liver fibrosis grading based on ultrasound showed a positive correlation.

conclusionS. japonicum infection contributes to an increase in MDSCs, especially G-MDSCs, whose proliferation may inhibit the number of

Indexed as

CD4-Positive T-LymphocytesLiver CirrhosisMyeloid-Derived Suppressor CellsSchistosomiasis japonicaAdultAgedAnimalsCell ProliferationChinaFemaleFlow CytometryHumansLeukocytes, MononuclearMaleMiddle AgedSchistosoma japonicumGranulocytic myeloid-derived suppressor cellsLiver fibrosisSchistosoma japonicum

Identifiers

PMID39212529
PMCPMC11363901

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.