Evidence map›Paper›PMID 39212418›Full record

ArticleEpilepsia2024

Timing of interventions to control neuronal chloride elevation in a model of neonatal seizures after hippocampal injury.

Volodymyr I Dzhala, Michelle Mail, Kevin J Staley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Volodymyr I DzhalaDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0001-2875-4352
Michelle MailDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kevin J StaleyDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Neuronal Ion and Volume Shifts After Acute Brain InjuryR35NS116852 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Kevin J. Staley · 2020 to 2026
$8.0M
Timing of Neuronal Chloride Uptake for Control of Neonatal SeizureR01NS120973 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Volodymyr Dzhala · 2022 to 2026
$2.0M
NINDS NIH HHS R01 NS120973NINDS NIH HHS R01NS120973 (V.D.)NINDS NIH HHS R35 NS116852NINDS NIH HHS R35 NS116852 (K.S.)
6 · The paper itself

Abstract

objectiveFollowing hypoxic-ischemic (HI) brain injury, neuronal cytoplasmic chloride concentration ([Cl

methodsSpontaneous neuronal network, neuronal [Cl

resultsIn vitro, murine intact hippocampi were free of ILDs for 12 h after preparation. Transient OGD resulted in a gradual increase in [Cl SIGNIFICANCE: The present age-specific group studies demonstrate that after OGD, NKCC1 transport activity significantly contributes to progressive [Cl

Indexed as

Animals, NewbornChloridesDisease Models, AnimalHippocampusNeuronsSeizuresSolute Carrier Family 12, Member 2AnimalsAnticonvulsantsBumetanidegamma-Aminobutyric AcidMiceMice, TransgenicPhenobarbitalSodium Potassium Chloride Symporter InhibitorsSodium-Potassium-Chloride SymportersAnticonvulsantsBumetanideChloridesgamma-Aminobutyric AcidPhenobarbitalSlc12a2 protein, mouseSodium Potassium Chloride Symporter InhibitorsSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2bumetanidehypoxia–ischemiaNKCC1phenobarbital, SuperClomeleon

Identifiers

PMID39212418
PMCPMC11573644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.