Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Claudia MickaelDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0002-1064-311X
Linda A SandersDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.ORCID 0009-0007-9902-4780
Michael H LeeDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-5739-8369
Rahul KumarDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-2709-5981
Dara Fonseca-BalladaresDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0009-0001-8427-5110
Aneta GandjevaCardiovascular Research Laboratories, University of Colorado, Aurora, Colorado, USA.ORCID 0009-0008-7379-6392
Kelly Cautivo-ReyesDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-4434-2814
Biruk KassaDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-9736-4876
Sushil KumarCardiovascular Research Laboratories, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0003-2290-2091
David IrwinCardiovascular Research Laboratories, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0002-1743-8266
Delaney SwindleCardiovascular Research Laboratories, University of Colorado, Aurora, Colorado, USA.ORCID 0009-0008-5521-6518
Tzu PhangSection of Hematology, Oncology, and Bone Marrow Transplantation-Cellular Therapeutics (BMT-CT), Department of Pediatrics, School of Medicine, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0002-4713-8782
Robert S StearmanDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-7628-7066
Ari B MolofskyDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-0764-3175
Amy S McKeeDepartment of Medicine, Division of Clinical Immunology, University of Colorado, Aurora, Colorado, USA.
Kurt R StenmarkCardiovascular Research Laboratories, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0001-6918-6411
Brian B GrahamDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-7541-2585
Rubin M TuderDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0001-9923-607X
Funding
Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DELANEY, CASSIDY A · 2020 to 2024
$14.1M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseasesR25HL146166 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Matthew Wayne DeCamp, Sonia Castro Flores · 2019 to 2026
$3.4M
Localization and function of tissue type 2 lymphocytes during mixed inflammationR01AI162806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ari B Molofsky · 2022 to 2026
$2.8M
The paradoxical response to iron in pulmonary hypertension of sickle cell diseaseR01HL161004 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUEHLER, PAUL WERNER, D'ALESSANDRO, ANGELO · 2022 to 2025
$2.7M
Aerosolized therapy for hemoglobin toxicity in the treatment of hemolytic diseasesR01HL158076 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUEHLER, PAUL WERNER, IRWIN, DAVID CHARLES · 2022 to 2025
$2.5M
Defining group 2 innate lymphoid cell lung nichesR01HL142701 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ARI B · 2019 to 2022
$2.5M
Meningeal type 2 immunity in cortical synapse remodeling during brain development and injuryR01NS126765 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anna V Molofsky, Ari B Molofsky · 2022 to 2026
$2.3M
The contribution of hypoxia inducible factor-1-dependent glycolysis in lung interstitial macrophages to the pathobiology of schistosomiasis-induced pulmonary hypertension.K08HL168310 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michael Hyunjean Lee · 2023 to 2026
$676k
Novel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary HypertensionK01HL161024 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Claudia Silva Mickael · 2022 to 2026
$661k
Actelion Pharmaceuticals (Actelion Pharmaceuticals Ltd)American Heart Association (AHA) 19CDA34730030American Thoracic Society (ATS)Cardiovascular Medical Research and Education Fund (CMREF)HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL161024HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K08HL168310HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) PO1HL152961HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01AI162806HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01 H161004HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL135872HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142701HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01NS126765HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R25HL146166NHLBI NIH HHS K01 HL161024NHLBI NIH HHS K08 HL168310NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R01 HL135872NHLBI NIH HHS R01 HL142701NHLBI NIH HHS R01 HL158076NHLBI NIH HHS R01 HL161004NHLBI NIH HHS R25 HL146166NIAID NIH HHS R01 AI162806NINDS NIH HHS R01 NS126765United Therapeutics Corporation (Uni Ther)U.S. Department of Defense (DOD) W81XWH2210457
6 · The paper itself
Abstract
Pulmonary hypertension (PH) is a chronic and progressive disease with significant morbidity and mortality. It is characterized by remodeled pulmonary vessels associated with perivascular and intravascular accumulation of inflammatory cells. Although there is compelling evidence that bone marrow-derived cells, such as macrophages and T cells, cluster in the vicinity of pulmonary vascular lesions in humans and contribute to PH development in different animal models, the role of dendritic cells in PH is less clear. Dendritic cells' involvement in PH is likely since they are responsible for coordinating innate and adaptive immune responses. We hypothesized that dendritic cells drive hypoxic PH. We demonstrate that a classical dendritic cell (cDC) subset (cDC2) is increased and activated in wild-type mouse lungs after hypoxia exposure. We observe significant protection after the depletion of cDCs in ZBTB46 DTR chimera mice before hypoxia exposure and after established hypoxic PH. In addition, we find that cDC depletion is associated with a reduced number of two macrophage subsets in the lung (FolR2
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension. · full record | OpenQuestion