Evidence map›Paper›PMID 39212292›Full record

ArticlePaediatric anaesthesia2024

Optimizing pediatric tonsillectomy outcomes with an opioid sparing anesthesia protocol: Learning and continuously improving with real-world data.

Jennifer L Chiem, Amber M Franz, Elizabeth E Hansen, Shilpa T Verma, Taylor F Stanzione, Leah K Bezzo, Michael J Richards, Sanjay R Parikh, John P Dahl, Daniel K Low and 1 more

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In one paragraph

Article in Paediatric anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Clinical practice guideline for perioperative pain management in pediatric low-temperature plasma tonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Guideline
  2. Article
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jennifer L ChiemDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0003-4363-9157
Amber M FranzDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0001-6334-0916
Elizabeth E HansenDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0001-7388-2612
Shilpa T VermaDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.
Taylor F StanzioneDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.
Leah K BezzoDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.
Michael J RichardsDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0001-7243-6506
Sanjay R ParikhDepartment of Otolaryngology-Head and Neck Surgery, Seattle Children's Hospital, Seattle, Washington, USA.
John P DahlDepartment of Otolaryngology-Head and Neck Surgery, Seattle Children's Hospital, Seattle, Washington, USA.
Daniel K LowDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.
Lynn D MartinDepartment of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0001-9513-8763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis quality improvement initiative is a continued pursuit to optimize outcomes by iteratively improving our opioid sparing anesthesia protocol for tonsillectomy with or without adenoidectomy at our pediatric ambulatory surgical center through data driven Plan-Do-Study-Act cycles.

methodsFrom 1/2015 through 12/2023, our standardized tonsillectomy protocol underwent nine procedure-specific perioperative Plan-Do-Study-Act cycles, three procedure-specific postoperative prescription Plan-Do-Study-Act cycles, and four general ambulatory surgical center enhanced recovery Plan-Do-Study-Act cycles. We analyzed data from the medical record using statistical process control charts. The primary outcome measure was the percent of patients requiring intravenous opioid in the post anesthesia care unit. Secondary outcomes included maximum post anesthesia care unit pain score, the percent of patients requiring treatment for nausea and/or vomiting in the post anesthesia care unit, and the number of postoperative opioid prescription dosages. Balancing measures were average post anesthesia care unit length of stay, percent of patients with prolonged Post Anesthesia Care Unit length of stay (>120 min), and 30-day reoperation rate.

resultsA total of 5654 tonsillectomy with or without adenoidectomy cases were performed at our ambulatory surgical center from 2015 to 2023. The incidence of intravenous opioid administered in the post anesthesia care unit initially rose with opioid free anesthesia launch, but subsequently decreased below the target of 10%. Maximum post anesthesia care unit pain scores rose from mean 3.6 to 4.5, but subsequently returned to the baseline of 3.5, while the incidence of postoperative nausea and/or vomiting improved. The average post anesthesia care unit length of stay increased by 10 min with opioid free anesthesia; however, prolonged post anesthesia care unit stay and 30-day reoperation rates were unchanged.

conclusionsThe continued refinement of our opioid sparing anesthesia protocol has led to reduced perioperative and home opioid use, stable maximum post anesthesia care unit pain scores, and improved postoperative nausea and vomiting rates, with only a slight increase in mean post anesthesia care unit length of stay.

Indexed as

Analgesics, OpioidPostoperative PainTonsillectomyAdenoidectomyAdolescentAnesthesiaChildChild, PreschoolFemaleHumansLength of StayMalePostoperative Nausea and VomitingQuality ImprovementTreatment OutcomeAnalgesics, Opioidambulatorygeneral anesthesiaobstructive sleep apneaopioidsotolaryngologyoutcomesoutpatientpainquality improvement

Identifiers

PMID39212292

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.