ReviewVeterinary medicine and science2024
Update on ketosis in dairy cattle with major emphasis on subclinical ketosis and abdominal adiposity.
Review in Veterinary medicine and science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Milk BHB Heritability Estimates and Genetic Correlations with Milk Yield in Grazing Dairies in Chile.JDS communications · 2026Article
- Hepatic lipidosis in feedlot cattle: report of two outbreaks.Veterinary research communications · 2026Article
- Physiological Variables, Milk Conductivity and Production in Dairy Cows to Ketosis During the Transition Period in Northern Mexico.Veterinary sciences · 2026Article
- A One Health Framework for Proteomics Across the Tree of Life to Advance Food Security, Animal Health, and Ecosystem Resilience.Proteomes · 2026Review
- Balancing High Yield and Metabolic Health in Dairy Ruminants: The Central Hub Role of the Rumen Microbiota.Veterinary sciences · 2026Review
- Prevalence and economic impact of subclinical ketosis on smallholder farms of Holstein-Friesian-Zebu crossbred cows.Veterinary and animal science · 2026Article
- Metagenomic Insights into the Modulatory Effects of Thiamine Supplementation for Treating Subclinical Ketosis Dairy Cows.Animals : an open access journal from MDPI · 2026Article
- Endocrine-metabolic regulation during the transition period in dairy cows: mechanisms, biomarkers, and emerging diagnostics for subclinical ketosis.Frontiers in endocrinology · 2026Review
- Routine milk records reveal novel two-way interactions shaping ketosis risk in German dairy cows.PloS one · 2026Article
- Metabolomic insights into thiamine-mediated metabolism in treating subclinical ketosis in dairy cows.Frontiers in veterinary science · 2026Article
- Identification of genes related to ketosis in dairy cows and establishment of early detection method for aryl hydrocarbon receptor gene.Frontiers in veterinary science · 2026Article
- The gut-liver axis in animal diseases: roles, mechanisms, and veterinary clinical applications.Frontiers in veterinary science · 2026Review
- Current Understanding of Bovine Ketosis: From Molecular Basis to Farm-Level Management.Animals : an open access journal from MDPI · 2025Review
- Subclinical Ketosis: Reproductive Performance and Milk Yield in Dairy Cows Receiving Oral Glucogenic Precursors During Early Postpartum Period.Veterinary medicine and science · 2025Article
- Body condition score at calving, subclinical ketosis, postpartum body condition score losses, diseases, and fertility in Holstein cows: modelling confounding associations.Veterinary and animal science · 2025Article
- NDUFAB1 as a Novel Regulator of NEFA-Induced Metabolic Dysfunction in Bovine Adipocytes.Animals : an open access journal from MDPI · 2025Article
- Validation of the Measurement of Beta-Hydroxybutyrate and Non-Esterified Fatty Acids in Bovine Saliva: A Pilot Report.Life (Basel, Switzerland) · 2025Article
- Rutin Ameliorates BHBA-Induced Inflammation and Lipid Accumulation in Calf Hepatocytes Through NF-κB Signaling Pathway.Current issues in molecular biology · 2025Article
- Update on ketosis in dairy cattle with major emphasis on subclinical ketosis and abdominal adiposity.Veterinary medicine and science · 2024Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic changes that occur during the early post-partum period in dairy cows can indeed lead to an imbalance in energy utilization, resulting in the production of excessive ketone bodies. This can have detrimental effects on the cow's health and milk production, leading to economic losses for dairy producers. The release of non-esterified fatty acids into the blood due to increased lipolysis is a key factor in the development of ketosis. Abdominal adiposity is a key factor on these outcomes in modern dairy cows. The redirection of energy and glucose towards lactose synthesis and milk yield leaves a deficit of gluconeogenic precursors, leading to the conversion of acetyl-CoA into ketone bodies instead of entering the Krebs cycle. These ketone bodies, including acetone, acetoacetate and β-hydroxybutyrate, accumulate in the blood and can be detected in various bodily fluids, such as urine, blood and milk, allowing for diagnostic testing. Prevention is indeed crucial in managing ketosis in dairy cattle. Supplementation of propylene glycol in the diet or the use of monensin, either in the diet or in the form of a slow-release bolus, can help prevent the occurrence of ketosis. However, avoiding high body condition (subcutaneous fat) and excessive abdominal adiposity during the dry period and parturition plus an adequate cow comfort are fundamental tasks to avoid ketosis and related disorders. These interventions aim to provide additional energy sources or enhance the cow's ability to utilize energy efficiently, thus reducing the reliance on excessive lipolysis and ketone body production.
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