Evidence map›Paper›PMID 39211858›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic bvFTD.

Ting Shen, Jacob W Vogel, Vivianna M Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S Phillips, Lauren Massimo, Edward B Lee, David J Irwin, Corey T McMillan

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ting Shen
Jacob W Vogel
Vivianna M Van Deerlin
EunRan Suh
Laynie Dratch
Jeffrey S Phillips
Lauren Massimo
Edward B Lee
David J Irwin
Corey T McMillan

Funding

Spreading Tau Pathology in Non-Amnestic Alzheimer's DiseaseR01AG054519 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jeffrey S Phillips · 2018 to 2026
$7.4M
A Network Neuroscience Investigation of Disease Spread in Non-Amnestic Mild Cognitive ImpairmentK01AG061277 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PHILLIPS, JEFFREY S · 2019 to 2023
$583k
NIA NIH HHS K01 AG061277NIA NIH HHS R01 AG054519
6 · The paper itself

Abstract

Cortical atrophy in behavioral variant frontotemporal degeneration (bvFTD) exhibits spatial heterogeneity across genetic subgroups, potentially driven by distinct biological mechanisms. Using an integrative imaging-transcriptomics approach, we identified disparate and shared transcriptomic signatures associated with cortical thickness in

Identifiers

PMID39211858
PMCPMC11361203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.