ArticlemedRxiv : the preprint server for health sciences2025
An atlas of genetic effects on the monocyte methylome across European and African populations.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Elucidating the genetic architecture of DNA methylation (DNAm) is crucial for decoding complex disease etiology. However, current epigenomic studies are often constrained by limited methylation coverage and tissue heterogeneity. Here, we present the first comprehensive, multi-ancestry methylome atlas of purified human monocytes, which play a central role in immune response and inflammation, generated through integrated whole-genome bisulfite sequencing and whole-genome sequencing from 160 African Americans (AA) and 298 European Americans (EA). By analyzing over 25 million CpG sites, we identified 3,634,383 and 3,261,407 CpG sites having
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