Evidence map›Paper›PMID 39211730›Full record

ArticleComprehensive psychoneuroendocrinology2024

Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity.

Shanshan Xiao, Håkan Fischer, Natalie C Ebner, Gull Rukh, Junhua Dang, Lars Westberg, Helgi B Schiöth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The psychedelic-peptide paradox: a hormetic hypothesis.Comprehensive psychoneuroendocrinology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shanshan XiaoDepartment of Psychology, Stockholm University, Campus Albano house 4, Albanovägen, SE-114 19, Stockholm, Sweden.
Håkan FischerDepartment of Psychology, Stockholm University, Campus Albano house 4, Albanovägen, SE-114 19, Stockholm, Sweden.
Natalie C EbnerDepartment of Psychology, University of Florida, P.O. Box 112250, Gainesville, FL, 32611-2250, USA.
Gull RukhDepartment of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, BMC, Husargatan 3, 75124, Uppsala, Sweden.
Junhua DangInstitute of Social Psychology, School of Humanities and Social Sciences, Xi'an Jiaotong University, No.28 Xianning West Road, Xi'an, Shaanxi, 710049, PR China.
Lars WestbergDepartment of Pharmacology, Institute of Neuroscience and Physiology at the Sahlgrenska Academy, University of Gothenburg, Box 431, SE-405 30, Gothenburg, Sweden.
Helgi B SchiöthDepartment of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, BMC, Husargatan 3, 75124, Uppsala, Sweden.

Funding

Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
The potential of oxytocin to reduce opioid abuse liability and pain among older adultsR21DA056813 · NIDA · UNIVERSITY OF FLORIDA · PI BERRY, MEREDITH, CRUZ-ALMEIDA, YENISEL · 2023 to 2024
$419k
NIA NIH HHS R01 AG059809NIDA NIH HHS R21 DA056813
6 · The paper itself

Abstract

Genetic variations in single nucleotide polymorphisms (SNPs) within oxytocin pathway genes have been linked to social behavior and neurodevelopmental conditions. However, the neurobiological mechanisms underlying these associations remain elusive. In this study, we investigated the relationship between variations of 10 SNPs in oxytocin pathway genes and resting-state functional connectivity among 55 independent components using a large sample from the UK Biobank (N ≈ 30,000). Our findings revealed that individuals with the GG genotype at rs4813627 within the oxytocin structural gene (

Indexed as

Corticostriatal connectivityOxytocin pathway geneResting-state functional connectivityUK Biobank

Identifiers

PMID39211730
PMCPMC11357861

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.