Evidence map›Paper›PMID 39211597›Full record

ArticleJACS Au2024

An Enzymatic Oxidation Cascade Converts δ-Thiolactone Anthracene to Anthraquinone in the Biosynthesis of Anthraquinone-Fused Enediynes.

Guang-Lei Ma, Wan-Qiu Liu, Huawei Huang, Xin-Fu Yan, Wei Shen, Surawit Visitsatthawong, Kridsadakorn Prakinee, Hoa Tran, Xiaohui Fan, Yong-Gui Gao and 3 more

Abstract read
In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guang-Lei MaSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Wan-Qiu LiuSchool of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Huawei HuangSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Xin-Fu YanSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Wei ShenNational Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing 314100, China.
Surawit VisitsatthawongSchool of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley, Rayong 21210, Thailand.
Kridsadakorn PrakineeSchool of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley, Rayong 21210, Thailand.ORCID https://orcid.org/0000-0003-2421-1518
Hoa TranSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Xiaohui FanCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID https://orcid.org/0000-0002-6336-3007
Yong-Gui GaoSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Pimchai ChaiyenSchool of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley, Rayong 21210, Thailand.ORCID https://orcid.org/0000-0002-8533-1604
Jian LiSchool of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.ORCID https://orcid.org/0000-0003-2359-238X
Zhao-Xun LiangSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.ORCID https://orcid.org/0000-0002-3128-1330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anthraquinone-fused enediynes are anticancer natural products featuring a DNA-intercalating anthraquinone moiety. Despite recent insights into anthraquinone-fused enediyne (AQE) biosynthesis, the enzymatic steps involved in anthraquinone biogenesis remain to be elucidated. Through a combination of

Identifiers

PMID39211597
PMCPMC11350584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.