Evidence map›Paper›PMID 39211482›Full record

ArticleHemato2021

Barriers and Facilitators of Use of Hydroxyurea among Children with Sickle Cell Disease: Experiences of Stakeholders in Tanzania.

Manase Kilonzi, Hamu J Mlyuka, Fatuma Felix Felician, Dorkasi L Mwakawanga, Lulu Chirande, David T Myemba, Godfrey Sambayi, Ritah F Mutagonda, Wigilya P Mikomangwa, Joyce Ndunguru and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hemato, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Manase KilonziSchool of Pharmacy, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Hamu J MlyukaSchool of Pharmacy, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Fatuma Felix FelicianSchool of Pharmacy, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Dorkasi L MwakawangaSchool of Nursing, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Lulu ChirandeSchool of Medicine, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
David T MyembaSchool of Pharmacy, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Godfrey SambayiSchool of Pharmacy, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Ritah F MutagondaSchool of Pharmacy, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Wigilya P MikomangwaSchool of Pharmacy, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Joyce NdunguruSchool of Medicine, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
Agnes JonathanSchool of Medicine, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
Paschal RuggajoSchool of Medicine, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
Irene Kida MinjaSchool of Dentistry, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.
Emmanuel BalandyaSchool of Medicine, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
Julie MakaniSchool of Medicine, The Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
Nathanael SiriliDepartment of Development Studies, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65013, Tanzania.

Funding

Sickle Pan-African Research Consortium (SPARCO)- TanzaniaU01HL156853 · NHLBI · MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS · PI BALANDYA, EMMANUEL · 2021 to 2025
$1.5M
NHLBI NIH HHS U01 HL156853
6 · The paper itself

Abstract

Factors contributing to low use of HU among SCD patients exist in high-income countries. The latter leaves a drift of literature on factors for low utilization of HU in developing countries. This study aimed to explore the factors influencing the use of HU in the management of SCD in Tanzania. A qualitative study was employed to interview purposively selected participants for this study. The in-depth interviews were conducted with 11 parents of children with SCD, four medical doctors working at sickle cell clinics, and two representatives of the national health insurance fund (NHIF). Interviews were audio-recorded, transcribed, and thematically analysed. Barriers identified were misconception of parents on SCD, financial constraints, regulatory restrictions, worries and fears of medical doctors on the acceptability of HU, shortages of laboratory equipment and consumables, and limited availability of HU. Adequate knowledge of the parents and medical doctors on SCD and HU and opportunities for HU accessibility were the facilitators identified. The utilization of HU by the individual with SCD is affected by several factors, from individual to policy level. Nevertheless, parents of children with SCD and medical doctors working in sickle cell clinics demonstrated good knowledge of the diseases and HU.

Indexed as

barriersfacilitatorshydroxyureautilization

Identifiers

PMID39211482
PMCPMC11361318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.