Evidence map›Paper›PMID 39211477›Full record

ArticleRSC chemical biology2024

Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis.

Gabriel M Kline, Nicole Madrazo, Christian M Cole, Meera Pannikkat, Michael J Bollong, Jessica D Rosarda, Jeffery W Kelly, R Luke Wiseman

Abstract read
In one paragraph

Article in RSC chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriel M KlineDepartment of Chemistry, The Scripps Research Institute La Jolla CA 92037 USA jkelly@scripps.edu.
Nicole MadrazoDepartment of Molecular and Cellular Biology, The Scripps Research Institute La Jolla CA 92037 USA wiseman@scripps.edu.ORCID https://orcid.org/0000-0003-3731-0451
Christian M ColeDepartment of Chemistry, The Scripps Research Institute La Jolla CA 92037 USA jkelly@scripps.edu.
Meera PannikkatDepartment of Molecular and Cellular Biology, The Scripps Research Institute La Jolla CA 92037 USA wiseman@scripps.edu.
Michael J BollongDepartment of Chemistry, The Scripps Research Institute La Jolla CA 92037 USA jkelly@scripps.edu.ORCID https://orcid.org/0000-0001-9439-1476
Jessica D RosardaDepartment of Molecular and Cellular Biology, The Scripps Research Institute La Jolla CA 92037 USA wiseman@scripps.edu.ORCID https://orcid.org/0000-0002-2742-7413
Jeffery W KellyDepartment of Chemistry, The Scripps Research Institute La Jolla CA 92037 USA jkelly@scripps.edu.ORCID https://orcid.org/0000-0001-8943-3395
R Luke WisemanDepartment of Molecular and Cellular Biology, The Scripps Research Institute La Jolla CA 92037 USA wiseman@scripps.edu.

Funding

Discovering small molecules activators of stress responsive signalingR01AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI JEFFERY W KELLY, Rockland Luke Wiseman · 2013 to 2026
$6.0M
Discovering Small Molecule Activators of Stress-Responsive SignalingRF1AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W, WISEMAN, ROCKLAND LUKE · 2023 to 2025
$2.8M
NIA NIH HHS R01 AG046495NIA NIH HHS RF1 AG046495
6 · The paper itself

Abstract

We previously showed that the proteostasis regulator compound AA147 (

Identifiers

PMID39211477
PMCPMC11353103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.