Evidence map›Paper›PMID 39211438›Full record

ArticleNature. Mental health2024

On the issue of treating HIV in people with syndemic mental-health and substance-use disorders.

David J Grelotti, Jessica Montoya, Violaine Delorme-Walker, Jennifer Iudicello, Ronald Ellis, Igor Grant, Scott Letendre, Maria Cecilia Garibaldi Marcondes, Mariana Cherner

Abstract read
In one paragraph

Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David J GrelottiDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, 92121.
Jessica MontoyaDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, 92121.
Violaine Delorme-WalkerSan Diego Biomedical Research Institute, San Diego, CA, 92121.
Jennifer IudicelloDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, 92121.
Ronald EllisDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, 92121.
Igor GrantDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, 92121.
Scott LetendreDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, 92121.
Maria Cecilia Garibaldi MarcondesSan Diego Biomedical Research Institute, San Diego, CA, 92121.
Mariana ChernerDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, 92121.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
Cannabis and Pathogenic Mechanisms influencing Blood Brain Barrier Function in HIVR01DA058405 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jerel Adam Fields, Jennifer E Iudicello · 2023 to 2026
$5.0M
Identification of Biomarkers of CNS injury and resilience related to HIV-1 and MethamphetamineR01DA047879 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IUDICELLO, JENNIFER E, LETENDRE, SCOTT L · 2018 to 2022
$3.7M
Molecular effects of cannabinoids on the Blood Brain Barrier in HIV-infected brainR01DA059344 · NIDA · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI D. Richard MILNER, Maria Cecilia Garibaldi Marcondes · 2024 to 2026
$2.4M
Methamphetamine, HIV integration and latency in the brainR33DA059924 · NIDA · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI Maria Cecilia Garibaldi Marcondes · 2025 to 2026
$1.6M
Methamphetamine, HIV integration and latency in the brainR61DA059924 · NIDA · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI MARCONDES, MARIA CECILIA GARIBALDI · 2023 to 2024
$1.2M
An integrated incentive-based treatment to optimize HIV treatment engagement among persons who use methamphetamineK23DA051324 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MONTOYA, JESSICA LYNETTE · 2021 to 2025
$1.0M
NIAID NIH HHS P30 AI036214NIDA NIH HHS K23 DA051324NIDA NIH HHS R01 DA047879NIDA NIH HHS R01 DA058405NIDA NIH HHS R01 DA059344NIDA NIH HHS R33 DA059924NIDA NIH HHS R61 DA059924NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

People with HIV and comorbid substance use problems may be among those who benefit most from long-acting HIV antiretroviral treatment, but they are routinely excluded from Phase 3 clinical trials. Their inclusion would permit an examination of the clinical value of long-acting therapies for people with adherence problems and an exploration of syndemic interactions between HIV, mental health conditions, and substance use problems, which compound into a major challenge in the efforts to end the HIV epidemic.

Identifiers

PMID39211438
PMCPMC11360833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.