Evidence map›Paper›PMID 39211298›Full record

ArticleAdvanced materials technologies2023

Injectable polysaccharide hydrogels as localized nitric oxide delivery formulations.

Evan S Feura, Sara E Maloney, Ivie L Conlon, Christopher A Broberg, Feichen Yang, Mark H Schoenfisch

Abstract read
In one paragraph

Article in Advanced materials technologies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Evan S FeuraDepartment of Chemistry, University of North Carolina at Chapel Hill CB 3290, Chapel Hill, NC 27599.
Sara E MaloneyDepartment of Chemistry, University of North Carolina at Chapel Hill CB 3290, Chapel Hill, NC 27599.
Ivie L ConlonDepartment of Chemistry, University of North Carolina at Chapel Hill CB 3290, Chapel Hill, NC 27599.
Christopher A BrobergDepartment of Chemistry, University of North Carolina at Chapel Hill CB 3290, Chapel Hill, NC 27599.
Feichen YangDepartment of Chemistry, University of North Carolina at Chapel Hill CB 3290, Chapel Hill, NC 27599.
Mark H SchoenfischDepartment of Chemistry, University of North Carolina at Chapel Hill CB 3290, Chapel Hill, NC 27599.

Funding

Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal diseaseR01DE032060 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark H Schoenfisch, Shannon Margaret Wallet · 2023 to 2026
$2.0M
Nitric oxide-releasing glycosaminoglycans for treating complex woundsR01DK132778 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark H Schoenfisch, Shannon Margaret Wallet · 2023 to 2026
$1.5M
NIDCR NIH HHS R01 DE032060NIDDK NIH HHS R01 DK132778
6 · The paper itself

Abstract

A series of injectable polysaccharide hydrogels were prepared with oxidized dextran and diethylenetriamine-modified carboxymethylcellulose or hyaluronic acid. Rheological evaluation revealed that carboxymethylcellulose-based hydrogels achieved the largest storage moduli (>1 kPa) when prepared from 5 wt. % solutions. However, carboxymethylcellulose-based hydrogels with storage moduli >100 Pa were prepared from solutions with concentrations as low as 2 wt. %. Hyaluronic acid-based hydrogels demonstrated smaller storage moduli but had swelling ratios more than four times that of the carboxymethylcellulose systems at the same polymer concentrations. The incorporation of

Indexed as

carboxymethylcellulosedextranhyaluronic acidinjectable hydrogelnitric oxidepolysaccharide

Identifiers

PMID39211298
PMCPMC11361346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.