Evidence map›Paper›PMID 39211239›Full record

ArticlebioRxiv : the preprint server for biology2024

Senescent cell clearance ameliorates temporal lobe epilepsy and associated spatial memory deficits in mice.

Tahiyana Khan, David J McFall, Abbas I Hussain, Logan A Frayser, Timothy P Casilli, Meaghan C Steck, Irene Sanchez-Brualla, Noah M Kuehn, Michelle Cho, Jacqueline A Barnes and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Abbas I Hussain
Logan A Frayser
Timothy P Casilli
Meaghan C Steck
Irene Sanchez-BruallaORCID 0000-0002-1992-150X
Noah M Kuehn
Michelle Cho
Jacqueline A Barnes
Patrick A ForcelliORCID 0000-0003-1763-060X

Funding

Targeting cellular senescence to prevent epileptogenesisR21NS125552 · NINDS · GEORGETOWN UNIVERSITY · PI FORCELLI, PATRICK ALEXANDER · 2022 to 2022
$429k
The contribution of cellular senescence in epileptogenesisF99NS129108 · NINDS · GEORGETOWN UNIVERSITY · PI KHAN, TAHIYANA · 2022 to 2023
$71k
NINDS NIH HHS F99 NS129108NINDS NIH HHS R21 NS125552
6 · The paper itself

Abstract

Current therapies for the epilepsies only treat the symptoms, but do not prevent epileptogenesis (the process in which epilepsy develops). Many cellular responses during epileptogenesis are also common hallmarks of

Identifiers

PMID39211239
PMCPMC11360968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.