Evidence map›Paper›PMID 39211220›Full record

ArticlebioRxiv : the preprint server for biology2024

An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.

Cinzia Vicidomini, Travis D Goode, Kathleen M McAvoy, Ruilin Yu, Conor H Beveridge, Sanjay N Iyer, Matheus B Victor, Noelle Leary, Liam Evans, Michael J Steinbaugh and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Cinzia VicidominiCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Travis D GoodeCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-1432-8894
Kathleen M McAvoyCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ruilin YuDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Conor H BeveridgeDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Sanjay N IyerDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Matheus B VictorPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Noelle LearyPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Liam EvansCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael J SteinbaughHarvard Chan Bioinformatics Core, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA.
Zon Weng LaiHarvard Chan Advanced Multi-omics Platform, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Marina C LyonCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Manuel Rico F S SilvestreCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Gracia BonillaDepartment of Molecular Biology. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ruslan I SadreyevDepartment of Molecular Biology. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tobias C WaltherHarvard Chan Advanced Multi-omics Platform, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Shannan Ho SuiHarvard Chan Bioinformatics Core, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA.
Takaomi SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198 Japan.ORCID 0000-0003-1970-6903
Kei YamamotoGraduate School of Technology, Industrial and Social Sciences, Tokushima University, 2-1 Minami-jyosanjima, Tokushima 770-8513, Japan.
Makoto MurakamiLaboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Li-Huei TsaiBROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0003-1262-0592
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Amar SahayCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Targeting neurogenesis-inhibition coupling to improve memory in aging\Diversity SupplementR01AG076612 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Amar Sahay · 2022 to 2026
$3.8M
Contributions of hippocampal oxytocin receptors to social recognitionR01MH111729 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SAHAY, AMAR · 2018 to 2022
$2.4M
Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognitionR01MH131652 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Amar Sahay · 2023 to 2026
$2.4M
Development of a high throughput system for molecular imaging of different cell types in mouse brain tissuesRF1MH128866 · NIMH · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, LASKIN, JULIA · 2021 to 2021
$1.5M
Chemical instruments-aware distributed blockchain based open AI platform to accelerate drug discoveryU18TR004146 · NCATS · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, JAYACHANDRAN, GUHA · 2022 to 2023
$1.1M
A Genetically Defined Lateral Septum Circuit for Contextual Calibration of Food Reward-SeekingK99MH132768 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI GOODE, TRAVIS DAVID · 2023 to 2024
$262k
NCATS NIH HHS U18 TR004146NCI NIH HHS P30 CA023168NIA NIH HHS R01 AG076612NIMH NIH HHS K99 MH132768NIMH NIH HHS R01 MH111729NIMH NIH HHS R01 MH131652NIMH NIH HHS RF1 MH128866
6 · The paper itself

Abstract

Breakdown of lipid homeostasis is thought to contribute to pathological aging, the largest risk factor for neurodegenerative disorders such as Alzheimer's Disease (AD). Cognitive reserve theory posits a role for compensatory mechanisms in the aging brain in preserving neuronal circuit functions, staving off cognitive decline, and mitigating risk for AD. However, the identities of such mechanisms have remained elusive. A screen for hippocampal dentate granule cell (DGC) synapse loss-induced factors identified a secreted phospholipase

Identifiers

PMID39211220
PMCPMC11361190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.