Evidence map›Paper›PMID 39211194›Full record

ArticlebioRxiv : the preprint server for biology2024

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development.

Natalie Samper, Lilja Harðardóttir, Delphine M Depierreux, Soomin C Song, Ayano Nakazawa, Ivan Gando, Tomoe Y Nakamura, Andrew M Sharkey, Carla R Nowosad, Stefan Feske and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Natalie Samper
Lilja Harðardóttir
Delphine M Depierreux
Soomin C Song
Ayano Nakazawa
Ivan Gando
Tomoe Y Nakamura
Andrew M Sharkey
Carla R Nowosad
Stefan Feske
Francesco Colucci
William A CoetzeeORCID 0000-0003-1522-8326

Funding

Roles of Endothelial and Smooth Muscle KATP Channels in Myocardial Ischemic InjuryR01HL146514 · NHLBI · LSU HEALTH SCIENCES CENTER · PI COETZEE, WILLIAM A, LEFER, DAVID JOSEPH · 2020 to 2023
$3.0M
Functional interaction between cardiac Na channels and KATP channelsR01HL148609 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A, DELMAR, MARIO · 2020 to 2023
$2.7M
Conditional knockout mice lacking K(ATP) channel subunitsR21HL093563 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A · 2009 to 2010
$465k
NHLBI NIH HHS R01 HL146514NHLBI NIH HHS R01 HL148609NHLBI NIH HHS R21 HL093563
6 · The paper itself

Abstract

Involved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to enhance NK-cell function, but none use ion channel modulators, which are widely used in clinical practice to treat hypertension, diabetes, epilepsy, and other conditions. Little is known about ion channels in NK cells. We show that

Identifiers

PMID39211194
PMCPMC11361148

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.