ArticlebioRxiv : the preprint server for biology2024
Circadian clock disruption and growth of kidney cysts in autosomal dominant polycystic kidney disease.
Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the Methods: To disrupt the circadian clock, we deleted Results: Human nephrectomy ADPKD kidneys and Conclusion: Renal collecting duct specific Key points: Lack of BMAL1, a circadian clock protein in renal collecting ducts disrupted the clock and increased cyst growth and fibrosis in an ADPKD mouse model.BMAL1 gene deletion increased cell proliferation by increasing lipogenesis in kidney cells.Thus, circadian clock disruption could be a risk factor for accelerated disease progression in patients with ADPKD.
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