Evidence map›Paper›PMID 39210624›Full record

ArticleJournal of cachexia, sarcopenia and muscle2024

Leptin signalling altered in infantile nephropathic cystinosis-related bone disorder.

Wai W Cheung, Ping Zhou, Ronghao Zheng, Arieh Gertler, Eduardo A Oliveira, Robert H Mak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Long-term outcomes in nephropathic cystinosis: a review.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wai W CheungDivision of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, La Jolla, CA, USA.
Ping ZhouDepartment of Pediatric Nephrology and Rheumatology, Sichuan Provincial Maternity and Child Health Care Hospital, Sichuan Clinical Research Center for Pediatric Nephrology and The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China.
Ronghao ZhengDepartment of Pediatric Nephrology, Rheumatology, and Immunology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Arieh GertlerSchool of Biological and Population Health Sciences, Institute of Biochemistry, Food Science and Nutrition, Hebrew University of Jerusalem, Rehovot, Israel.
Eduardo A OliveiraDepartment of Pediatrics, Division of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Robert H MakDivision of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, La Jolla, CA, USA.

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
Targeting NLRP3 inflammasome for treating muscle complications of chronic kidney diseaseR01DK125811 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAK, ROBERT H · 2020 to 2022
$710k
2022 Key R&D Plan of Science and Technology Department of Sichuan Province 2022YFS0149Clinical Research Projects 23LCYJ015Cohort Study Project of the Institute's Science and Technology Innovation Fund of Sichuan Provincial Maternity and Child Health Care Hospital CXZD2023-01Cystinosis Research FoundationHealth Commission of Sichuan Province Technology ProjectsMedical Research Project of Chengdu Municipal Health Commission 2022113Medical Research Project of Sichuan ProvinceNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK 079337NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK125811NIH HHS R01 DK125811Science and Technology Fund of Chengdu Medical College CYZYB21-22Sichuan Medical Association S21037Young Investigator Grant of the National Kidney Foundation
6 · The paper itself

Abstract

backgroundThe CTNS gene mutation causes infantile nephropathic cystinosis (INC). Patients with INC develop Fanconi syndrome and chronic kidney disease (CKD) with significant bone deformations. C57BL/6 Ctns

methodsWe first defined the time course of bone abnormalities in Ctns

resultsBone defects are present in Ctns

conclusionsOur findings suggest a significant role for dysregulated leptin signalling in INC-related bone disorder, either directly or potentially involving a muscle-bone interplay. Leptin signalling blockade may represent a novel approach to treating bone disease as well as muscle wasting in INC.

Indexed as

CystinosisDisease Models, AnimalLeptinMice, KnockoutSignal TransductionAnimalsBone DiseasesHumansMiceMice, Inbred C57BLReceptor, Melanocortin, Type 4LeptinReceptor, Melanocortin, Type 4AgRPBoneInfantile nephropathic cystinosisLeptinMelanocortin receptor

Identifiers

PMID39210624
PMCPMC11634524

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.