ArticleParasites & vectors2024
Gustatory receptor 11 is involved in detecting the oviposition water of Asian tiger mosquito, Aedes albopictus.
Article in Parasites & vectors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026Review
- Contrasting Oviposition Preference Despite Limited Chemosensory Receptor Gene Differentiation in Two Cryptic Anopheles Species.Molecular ecology · 2026Article
- Gustatory sensing by ovipositor drives maternal avoidance of hesperidin to benefit the offspring in a major agricultural fly pest.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- Gustatory avoidance of fatty acids byProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Behavioral divergence between a generalist and a specialist mosquito despite minimal differentiation across chemosensory receptor gene families.bioRxiv : the preprint server for biology · 2025Article
- Insights into the autecology of Aedes albopictus.Parasites & vectors · 2025Review
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Abstract
backgroundAedes albopictus is a major arbovirus vector with small stagnant water containers being its oviposition sites. Mosquitoes search for these sites based on their olfactory cues (odor and moisture emanating from the water at the oviposition site), visual cues (size and color of the site), and gustatory cues (ion and nutrient concentration in that water). The gustatory mechanism through which mosquitoes search for oviposition sites remains unknown.
methodsTo investigate the role of taste receptors in Ae. albopictus oviposition site selection, we developed a laboratory model. This model assessed mosquito behavior in locating and detecting oviposition sites, using a location index to quantify site preference and detection time to measure response to water presence. We compared oviposition site-searching efficiency between mosquitoes with blocked and unblocked appendages, targeting the taste organs. Transcriptome sequencing was conducted to identify differentially expressed genes between water-exposed and unexposed mosquitoes. CRISPR/Cas9 technology was then employed to generate a mutant strain with a targeted gene knockout.
resultsThere was no significant difference between the blocked and unblocked groups in the location index. In contrast, the detection time of the unblocked group differed significantly from all other groups, including those with blocked foreleg tarsus, midleg tarsus, hindleg tarsus, all tibia, and all tarsus. Transcriptome sequencing analyses of water-exposed and unexposed mosquitoes revealed that the taste-related gene gustatory receptor 11(gr11) was differentially expressed. This gene was knocked out with CRISPR/Cas9 technology to generate a pure mutant strain with 2- and 4-bp deletions, which exhibited a significantly longer detection time than the wild-type strain.
conclusionsThis study reveals the role of Ae. albopictus gr11 in water detection at oviposition sites, thereby providing a theoretical basis and scientific guidelines for managing the breeding sites of these mosquitoes.
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