ArticleBMC public health2024
Psycho-social dimensions of cardiovascular risk: exploring the impact of social isolation and loneliness in middle-aged and older adults.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Loneliness among community-dwelling older adults across biological, clinical and psychosocial domains before and during the COVID-19 pandemic: a systematic review.Frontiers in public health · 2026Pooled it
- Coronary Artery Disease and Loneliness: A Cross-Sectional Analysis using the Revised UCLA Loneliness Scale.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026Article
- Adverse childhood experiences and risk of non-mental medical diseases in adulthood: an umbrella review.EClinicalMedicine · 2026Article
- Social Isolation and Incidence of Chest Pain and Mortality in Older Adults of the United States Population: A Cross-Sectional Study From NHANES 2001-2018.Health science reports · 2026Article
- Associations of Life-Course Social Isolation Trajectories and Depressive Symptoms With the Risk of Incident Cardiovascular Disease: A Prospective Cohort Study.Depression and anxiety · 2026Article
- Mental stress as a trigger of cardiovascular events: A narrative review.European journal of clinical investigation · 2026Review
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8 authors.
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Abstract
backgroundCardiovascular disease (CVD) is a major health concern for middle-aged and older adults, with lifestyle and metabolic risk factors well-studied. However, the role of psychosocial factors in CVD remains underexplored.
objectiveThis study aims to delve into the connection between psychosocial factors and the occurrence of CVD.
methodsWe utilized data from the UK Biobank, a large-scale study covering adults aged 38 to 73 recruited from various centers across the UK between 2006 and 2010. We employed Cox proportional hazards models to analyze the relationship between social isolation, loneliness, and incident CVD. CVD diagnoses were confirmed through hospital records and death-register data. Additionally, we conducted mediation analyses to assess the impact of low-grade inflammation.
resultsThe study encompassed 427,942 participants free from CVD, 55.8% of whom are women. High levels of social isolation and loneliness were linked to a higher risk of CVD (HRs 1.11, 95% CI 1.06-1.16; HRs 1.17, 95% CI 1.11-1.23). Depression also emerged as a predictor of CVD onset (HRs 1.25, 95% CI 1.19-1.31), with each psychosocial factor independently contributing to increased CVD risk. Mediation analyses pinpointed inflammation as a crucial mediator, especially for loneliness (indirect effect proportion: 4.7%).
conclusionsThis study underscores the significance of psychosocial factors in relation to CVD. Integrating assessments for social isolation, loneliness, and depression into routine healthcare could potentially aid in CVD prevention among middle-aged and elderly individuals. This study underscores the significance of psychosocial factors in relation to CVD, emphasizing the association between social isolation or loneliness and the heightened risk of CVD.
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