Evidence map›Paper›PMID 39210164›Full record

ArticleGeroScience2025

The effect of cognitive reserve on the cognitive connectome in healthy ageing.

Annegret Habich, Eloy Garcia-Cabello, Chiara Abbatantuono, Lissett Gonzalez-Burgos, Paolo Taurisano, Thomas Dierks, José Barroso, Daniel Ferreira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annegret HabichDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden. annegret.habich@ki.se.ORCID 0000-0002-2267-1206
Eloy Garcia-CabelloFacultad de Ciencias de La Salud, Universidad Fernando Pessoa Canarias, Las Palmas, Spain.
Chiara AbbatantuonoDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Lissett Gonzalez-BurgosDepartment of Clinical Psychology, Psychobiology and Methodology, Faculty of Psychology, University of La Laguna, La Laguna, Spain.
Paolo TaurisanoUniversity of Bari Aldo Moro, Bari, Italy.
Thomas DierksUniversity Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
José BarrosoFacultad de Ciencias de La Salud, Universidad Fernando Pessoa Canarias, Las Palmas, Spain.
Daniel FerreiraDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden. daniel.ferreira.padilla@ki.se.ORCID 0000-0001-9522-4338

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During ageing, different cognitive functions decline at different rates. Additionally, cognitive reserve may influence inter-individual variability in age-related cognitive decline. These complex relationships can be studied by constructing a so-called cognitive connectome and characterising it with advanced graph-theoretical network analyses. This study examined the effect of cognitive reserve on the cognitive connectome across age. A total of 334 cognitively healthy participants were stratified into early middle age (37-50 years; n = 110), late middle age (51-64 years; n = 106), and elderly (65-78 years; n = 118) groups. Within each age group, individuals were subdivided into high and low cognitive reserve. For each subgroup, a cognitive connectome was constructed based on correlations between 47 cognitive variables. Applying graph theory, different global network measures were compared between the groups. Graph-theoretical network analyses revealed that individuals with high cognitive reserve were characterized by a stable cognitive connectome across age groups. High cognitive reserve groups only differed in modularity. In contrast, individuals with low cognitive reserve showed a marked reconfiguration of cognitive connectomes across age groups with differences extending over a variety of network measures including network strength, global efficiency, modularity, and small-worldness. Our results suggest a stabilizing effect of cognitive reserve on the cognitive connectome. Gaining further insights into these findings and underlying mechanisms will contribute to our understanding of age-related cognitive decline and guide the development of strategies to preserve cognitive function in ageing.

Indexed as

AgingCognitive ReserveConnectomeHealthy AgingAdultAgedCognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedAgeingCognitive networkCognitive reserveGraph theoryNetwork analysis

Identifiers

PMID39210164
PMCPMC12181591

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.