Evidence map›Paper›PMID 39210042›Full record

ArticleActa pharmacologica Sinica2025

Preclinical characterization of [

Kai Liao, Jia-Hui Chen, Jie Ma, Chen-Chen Dong, Chun-Yang Bi, Ya-Biao Gao, Yuan-Fang Jiang, Tao Wang, Hui-Yi Wei, Lu Hou and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. First human whole-body biodistribution and dosimetry analysis of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Development and evaluation of a novel deuterated fluorine-18 PET tracer for MAO-B imaging.American journal of nuclear medicine and molecular imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kai Liao *Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Jia-Hui Chen *Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Jie MaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Chen-Chen DongCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Chun-Yang BiDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Ya-Biao GaoDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Yuan-Fang JiangCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Tao WangGuangdong-Hong Kong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, 510632, China.
Hui-Yi WeiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Lu HouCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Jun-Qi HuCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Jun-Jie WeiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Chun-Yuan ZengCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Yin-Long LiDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Sen YanGuangdong-Hong Kong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, 510632, China.
Hao XuCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. txh@jnu.edu.cn.
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA. steven.liang@emory.edu.
Lu WangCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. l_wang1009@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positron emission tomography (PET) targeting translocator protein 18 kDa (TSPO) can be used for the noninvasive detection of neuroinflammation. Improved in vivo stability of a TSPO tracer is beneficial for minimizing the potential confounding effects of radiometabolites. Deuteration represents an important strategy for improving the pharmacokinetics and stability of existing drug molecules in the plasma. This study developed a novel tracer via the deuteration of [

Indexed as

BrainFluorine RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsReceptors, GABAAnimalsBrain IschemiaDisease Models, AnimalLipopolysaccharidesMacaca mulattaMaleMiceNeuroinflammatory DiseasesRatsRats, Sprague-DawleyFluorine-18Fluorine RadioisotopesLipopolysaccharidesRadiopharmaceuticalsReceptors, GABA18FD2-LW223neuroinflammationPETtranslocator protein 18 kDaTSPO

Identifiers

PMID39210042
PMCPMC11747005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.