Evidence map›Paper›PMID 39210004›Full record

ReviewMolecular biology reports2024

Nitric oxide in modulating oxidative stress mediated skeletal muscle insulin resistance.

Aamir Anwar, Shivang Shukla, Priya Pathak

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aamir AnwarDepartment of Pharmacology, Amity Institute of Pharmacy, Amity University (Lucknow Campus), Lucknow, Uttar Pradesh, 226010, India.
Shivang ShuklaDepartment of Pharmacology, Amity Institute of Pharmacy, Amity University (Lucknow Campus), Lucknow, Uttar Pradesh, 226010, India.
Priya PathakDepartment of Pharmacology, Amity Institute of Pharmacy, Amity University (Lucknow Campus), Lucknow, Uttar Pradesh, 226010, India. ppathak@lko.amity.edu.

Funding

Department of Science and Technology, Ministry of Science and Technology, India SPG/2021/003146
6 · The paper itself

Abstract

Insulin resistance (IR) being the major cause behind different metabolic disorders, has attracted a lot of attention. Epidemiological data shows marked rise in the cases over a period of time. Nitric oxide (NO), produced from nitric oxide synthases (NOS), is involved in a variety of biological functions, alteration in which causes various disorders like hypertension, atherosclerosis, and angiogenesis-associated disorders. IR has been found to be a contributing factor, which is associated with abnormal NO signalling. Skeletal muscle is essential for metabolism, both for its role in glucose uptake and its importance in metabolic disease. In this article, we give an overview of the significance of NO in oxidative stress (OS) mediated IR, describing its role in different conditions that are associated with skeletal muscle IR. NO is found to be involved in the activation of insulin receptor downstream pathway, which suggests absence of NO could lead to reduced glucose uptake, and may ultimately result in IR.

Indexed as

Insulin ResistanceMuscle, SkeletalNitric OxideOxidative StressSignal TransductionAnimalsGlucoseHumansInsulinNitric Oxide SynthaseReceptor, InsulinGlucoseInsulinNitric OxideNitric Oxide SynthaseReceptor, InsulinInsulin resistanceNitric oxideOxidative stressReactive oxygen speciesSkeletal muscle

Identifiers

PMID39210004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.