ArticleNature communications2024
Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Complementary and opponent value signals in the human brain support choosing the best and avoiding the worst.Nature communications · 2026Article
- Closed-loop readout of anterior insula high-gamma activity steers value-based decisions.Nature communications · 2026Article
- Ultrasound neuromodulation reveals distinct roles of the dorsal anterior cingulate cortex and anterior insula in learning.PLoS biology · 2026Article
- Effective connectivity of the insula as measured by cortico-cortical evoked potentials.medRxiv : the preprint server for health sciences · 2026Article
- Ventromedial prefrontal cortex attenuates the link between physiological heart rate reactions to unfairness and value computations in normative decision making.Social cognitive and affective neuroscience · 2026Article
- Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind.Nature communications · 2025Article
- Neural mechanisms of confidence propagation in hierarchical partially observable decision-making.iScience · 2025Article
- Social conformity is a heuristic when individual risky decision-making is disrupted.PLoS computational biology · 2024Article
- A nonlinear relationship of evoked responses following charge-balanced single-pulse electrical stimulation with varying pulse widths.Brain stimulationArticle
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Authors and funding
7 authors.
Funding
Abstract
Neural activity within the ventromedial prefrontal cortex (vmPFC) and anterior insula (aIns) is often associated with economic choices and confidence. However, it remains unclear whether these brain regions are causally related to these processes. To address this issue, we leveraged intracranial electrical stimulation (iES) data obtained from patients with epilepsy performing an economic choice task. Our results reveal opposite effects of stimulation on decision-making depending on its location along a dorso-ventral axis within each region. Specifically, stimulation of the ventral subregion within aIns reduces risk-taking by increasing participants' sensitivity to potential losses, whereas stimulation of the dorsal subregion of aIns and the ventral portion of the vmPFC increases risk-taking by reducing participants' sensitivity to losses. Moreover, stimulation of the aIns consistently decreases participants' confidence, regardless of its location within the aIns. These findings suggest the existence of functionally dissociated neural subregions and circuits causally involved in accepting or avoiding challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.