Evidence map›Paper›PMID 39209778›Full record

ArticleBMJ open2024

Antihypertensive deprescribing in frail long-term care residents (OptimizeBP): protocol for a prospective, randomised, open-label pragmatic trial.

Roni Y Kraut, Erik Youngson, Cheryl A Sadowski, Jeffrey A Bakal, Douglas Faulder, Christina S Korownyk, Ana Vucenovic, Dean T Eurich, Donna P Manca, Carina Lundby and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05047731 (Antihypertensive Deprescribing in Long-term Care), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05047731 nacompletednot on this map

Antihypertensive Deprescribing in Long-term Care: A Randomized Controlled Trial (OptimizeBP)

TypeinterventionalSponsorUniversity of AlbertaRan2021 to 2025Enrolled522ConditionsHypertension, FrailtyArmsAntihypertensive medication
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Roni Y KrautDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada rkraut@ualberta.ca.ORCID 0000-0003-3354-4955
Erik YoungsonProvincial Research Data Services, Alberta Health Services, Edmonton, Alberta, Canada.
Cheryl A SadowskiFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-4526-7054
Jeffrey A BakalProvincial Research Data Services, Alberta Health Services, Edmonton, Alberta, Canada.ORCID 0000-0002-3658-2554
Douglas FaulderDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.
Christina S KorownykDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-4953-9392
Ana VucenovicDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-8762-9383
Dean T EurichSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-2197-0463
Donna P MancaDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.
Carina LundbyClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Paul KiviDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.
Margaret ManvilleDepartment of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada.
Scott R GarrisonDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-7024-2158

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough antihypertensive medication use is common among frail older adults, observational studies in this population suggest blood pressure (BP) lowering may convey limited benefit and perhaps even harm. This protocol describes an antihypertensive deprescribing trial in frail older adults powered for mortality and morbidity outcomes. METHODS AND ANALYSIS: ETHICS AND DISSEMINATION: Ethics approval was obtained from the University of Alberta Health Ethics Review Board (Pro00097312) and results will be published in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: NCT05047731.

Indexed as

Antihypertensive AgentsDeprescriptionsFrail ElderlyHypertensionLong-Term CareAgedAged, 80 and overAlbertaFemaleHumansMalePragmatic Clinical Trials as TopicProspective StudiesAntihypertensive AgentsAged, 80 and overBlood PressureFrailtyHypertensionPolypharmacyRandomized Controlled Trial

Identifiers

PMID39209778
PMCPMC11404250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.