Evidence map›Paper›PMID 39209474›Full record

ReviewThe European respiratory journal2024

Pathology and pathobiology of pulmonary hypertension: current insights and future directions.

Christophe Guignabert, Jurjan Aman, Sébastien Bonnet, Peter Dorfmüller, Andrea J Olschewski, Soni Pullamsetti, Marlene Rabinovitch, Ralph T Schermuly, Marc Humbert, Kurt R Stenmark

Abstract readReview
In one paragraph

Review in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Functional characterisation ofThe European respiratory journal · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Clinical Updates in Pulmonary Hypertension.Reviews in cardiovascular medicine · 2026
    Review
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Christophe GuignabertUniversité Paris-Saclay, Hypertension Pulmonaire: Physiopathology and Innovation Thérapeutique, HPPIT, Faculté de Médecine, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0002-8545-4452
Jurjan AmanDepartment of Pulmonary Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Sébastien BonnetPulmonary Hypertension research group, Centre de Recherche de l'Institut de Cardiologie et de Pneumologie de Québec, Quebec City, QC, Canada.
Peter DorfmüllerDepartment of Pathology, University Hospital Giessen/Marburg, Giessen, Germany.ORCID https://orcid.org/0000-0003-2499-6829
Andrea J OlschewskiLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.ORCID https://orcid.org/0000-0002-8189-3634
Soni PullamsettiMax Planck Institute for Heart and Lung Research Bad Nauheim, Bad Nauheim, Germany.ORCID https://orcid.org/0000-0003-0440-8831
Marlene RabinovitchBASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
Ralph T SchermulyDepartment of Internal Medicine, German Center for Lung Research (DZL) Cardio-Pulmonary Institute (CPI).ORCID https://orcid.org/0000-0002-5167-6970
Marc HumbertUniversité Paris-Saclay, Hypertension Pulmonaire: Physiopathology and Innovation Thérapeutique, HPPIT, Faculté de Médecine, Le Kremlin-Bicêtre, France marc.humbert@aphp.fr.ORCID https://orcid.org/0000-0003-0703-2892
Kurt R StenmarkDevelopmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado, Denver, CO, USA.

Funding

The Cellular Response to Elafin in PAHP01HL108797 · NHLBI · STANFORD UNIVERSITY · PI RABINOVITCH, MARLENE · 2011 to 2021
$19.7M
The BMP-PPARy Axis and Pulmonary HypertensionR01HL087118 · NHLBI · STANFORD UNIVERSITY · PI RABINOVITCH, MARLENE · 2008 to 2022
$7.2M
Endothelial Injury, BMPR2 Dysfunction and Macrophage Activation Cause EndMT and PAHR01HL138473 · NHLBI · STANFORD UNIVERSITY · PI Mark Robert Nicolls, Marlene Rabinovitch · 2017 to 2026
$4.9M
High Shear Stress Alters Gene Regulation in Pulmonary Arterial HypertensionR01HL152134 · NHLBI · STANFORD UNIVERSITY · PI RABINOVITCH, MARLENE · 2021 to 2024
$2.9M
NHLBI NIH HHS P01 HL108797NHLBI NIH HHS R01 HL087118NHLBI NIH HHS R01 HL138473NHLBI NIH HHS R01 HL152134
6 · The paper itself

Abstract

In recent years, major advances have been made in the understanding of the cellular and molecular mechanisms driving pulmonary vascular remodelling in various forms of pulmonary hypertension, including pulmonary arterial hypertension, pulmonary hypertension associated with left heart disease, pulmonary hypertension associated with chronic lung disease and hypoxia, and chronic thromboembolic pulmonary hypertension. However, the survival rates for these different forms of pulmonary hypertension remain unsatisfactory, underscoring the crucial need to more effectively translate innovative scientific knowledge into healthcare interventions. In these proceedings of the 7th World Symposium on Pulmonary Hypertension, we delve into recent developments in the field of pathology and pathophysiology, prioritising them while questioning their relevance to different subsets of pulmonary hypertension. In addition, we explore how the latest omics and other technological advances can help us better and more rapidly understand the myriad basic mechanisms contributing to the initiation and progression of pulmonary vascular remodelling. Finally, we discuss strategies aimed at improving patient care, optimising drug development, and providing essential support to advance research in this field.

Indexed as

Hypertension, PulmonaryVascular RemodelingAnimalsCongresses as TopicHumansHypoxia

Identifiers

PMID39209474
PMCPMC11533988

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.