Evidence map›Paper›PMID 39208846›Full record

ArticleNature2024

Synthesis of non-canonical amino acids through dehydrogenative tailoring.

Xin Gu, Yu-An Zhang, Shuo Zhang, Leon Wang, Xiyun Ye, Gino Occhialini, Jonah Barbour, Bradley L Pentelute, Alison E Wendlandt

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Cobalt-catalyzed alkyne silylamidation unlocksNational science review · 2026
    Article
  11. Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Review
  12. Direct Editing of Cysteine to Electrophilic Alkyl Halides in Peptides.Journal of the American Chemical Society · 2025
    Article
  13. Article
  14. Article
  15. Synthesis through C(spAccounts of chemical research · 2025
    Article
  16. Article
  17. Hydrodealkenylative C(spJournal of the American Chemical Society · 2025
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin Gu *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-9615-1070
Yu-An Zhang *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Shuo ZhangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Leon WangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Xiyun YeDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gino OcchialiniDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-9682-1740
Jonah BarbourDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Bradley L PenteluteDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-7242-801X
Alison E WendlandtDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. awendlan@mit.edu.ORCID 0000-0003-2970-9817

Funding

Late Stage Stereochemical Editing to Transform the Synthesis of Bioactive MoleculesDP2GM146248 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WENDLANDT, ALISON · 2021 to 2024
$2.1M
NIGMS NIH HHS DP2 GM146248
6 · The paper itself

Abstract

Amino acids are essential building blocks in biology and chemistry. Whereas nature relies on a small number of amino acid structures, chemists desire access to a vast range of structurally diverse analogues

Indexed as

Amino AcidsChemistry Techniques, SyntheticHydrogenationAlkenesCatalysisOligopeptidesPhotochemical ProcessesAlkenesAmino AcidsOligopeptides

Identifiers

PMID39208846
PMCPMC11904927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.