Evidence map›Paper›PMID 39208802›Full record

ArticleDevelopmental cell2024

ERK synchronizes embryonic cleavages in Drosophila.

Liu Yang, Audrey Zhu, Javed M Aman, David Denberg, Marcus D Kilwein, Robert A Marmion, Alex N T Johnson, Alexey Veraksa, Mona Singh, Martin Wühr and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liu YangLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Audrey ZhuLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Javed M AmanLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Computer Science, Princeton University, Princeton, NJ 08544, USA.
David DenbergLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Program in Quantitative and Computational Biology, Princeton University, Princeton, NJ 08544, USA.
Marcus D KilweinDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Robert A MarmionLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Alex N T JohnsonLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Alexey VeraksaDepartment of Biology, University of Massachusetts Boston, Boston, MA 02125, USA.
Mona SinghLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Computer Science, Princeton University, Princeton, NJ 08544, USA.
Martin WührLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: wuhr@princeton.edu.
Stanislav Y ShvartsmanLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Program in Quantitative and Computational Biology, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Flatiron Institute, New York, NY 10010, USA. Electronic address: stas@princeton.edu.

Funding

Development of New Proteomics Technology and its Application to Study Cellular OrganizationR35GM128813 · NIGMS · PRINCETON UNIVERSITY · PI Martin Wühr · 2018 to 2026
$4.0M
Collective dynamics in cell clustersR01GM134204 · NIGMS · PRINCETON UNIVERSITY · PI Stanislav Y. Shvartsman · 2019 to 2026
$2.6M
Mechanisms of signal integration in developmental control of organ size and tissue patterningR01HD085870 · NICHD · UNIVERSITY OF MASSACHUSETTS BOSTON · PI VERAKSA, ALEXEY · 2016 to 2020
$1.6M
Mechanisms of signal integration in developmental control of organ size and tissue patterningR01GM141843 · NIGMS · UNIVERSITY OF MASSACHUSETTS BOSTON · PI VERAKSA, ALEXEY · 2021 to 2024
$1.2M
NICHD NIH HHS R01 HD085870NIGMS NIH HHS R01 GM134204NIGMS NIH HHS R01 GM141843NIGMS NIH HHS R35 GM128813
6 · The paper itself

Abstract

Extracellular-signal-regulated kinase (ERK) signaling controls development and homeostasis and is genetically deregulated in human diseases, including neurocognitive disorders and cancers. Although the list of ERK functions is vast and steadily growing, the full spectrum of processes controlled by any specific ERK activation event remains unknown. Here, we show how ERK functions can be systematically identified using targeted perturbations and global readouts of ERK activation. Our experimental model is the Drosophila embryo, where ERK signaling at the embryonic poles has thus far only been associated with the transcriptional patterning of the future larva. Through a combination of live imaging and phosphoproteomics, we demonstrated that ERK activation at the poles is also critical for maintaining the speed and synchrony of embryonic cleavages. The presented approach to interrogating phosphorylation networks identifies a hidden function of a well-studied signaling event and sets the stage for similar studies in other organisms.

Indexed as

Drosophila melanogasterDrosophila ProteinsExtracellular Signal-Regulated MAP KinasesAnimalsEmbryonic DevelopmentEmbryo, NonmammalianGene Expression Regulation, DevelopmentalLarvaMAP Kinase Signaling SystemPhosphorylationProteomicsSignal TransductionDrosophila ProteinsExtracellular Signal-Regulated MAP KinasesCdc25Cdk1cell cyclecleavagesembryonicERKoptogeneticsphosphoproteomesychrony

Identifiers

PMID39208802
PMCPMC11895397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.