Evidence map›Paper›PMID 39208752›Full record

ArticleVision research2024

Age-related effects of optineurin deficiency in the mouse eye.

Chien-Chia Su, Crystal Liu, Vishnu Adi, Kevin C Chan, Henry C Tseng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vision research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chien-Chia SuDuke Eye Center, Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Crystal LiuDepartments of Ophthalmology and Radiology, Neuroscience Institute, and Tech4Health Institute, New York University Grossman School of Medicine, New York, NY 10017, USA.
Vishnu AdiDepartments of Ophthalmology and Radiology, Neuroscience Institute, and Tech4Health Institute, New York University Grossman School of Medicine, New York, NY 10017, USA.
Kevin C ChanDepartments of Ophthalmology and Radiology, Neuroscience Institute, and Tech4Health Institute, New York University Grossman School of Medicine, New York, NY 10017, USA; Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY 11201, USA.
Henry C TsengDuke Eye Center, Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: henry.tseng@duke.edu.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
NEI Mentored Clincial Scientist Development Program Award (K12)K12EY016333 · NEI · DUKE UNIVERSITY · PI COUSINS, SCOTT W · 2004 to 2013
$5.4M
Negative regulation of NF-kB by optineurin in primary open angle glaucomaK08EY021520 · NEI · DUKE UNIVERSITY · PI TSENG, HENRY · 2011 to 2013
$526k
NEI NIH HHS K08 EY021520NEI NIH HHS K12 EY016333NEI NIH HHS P30 EY005722
6 · The paper itself

Abstract

Optineurin (OPTN) is a gene associated with familial normal tension glaucoma (NTG). While NTG involves intraocular pressure (IOP)-independent neurodegeneration of the visual pathway that progresses with age, how OPTN dysfunction leads to NTG remains unclear. Here, we generated an OPTN knockout mouse (Optn

Indexed as

AgingCell Cycle ProteinsIntraocular PressureLow Tension GlaucomaMembrane Transport ProteinsMice, KnockoutRetinal Ganglion CellsAnimalsDisease Models, AnimalElectroretinographyMiceMice, Inbred C57BLRetinaCell Cycle ProteinsMembrane Transport ProteinsOptn protein, mouseGlaucoma geneticsMouse modelNormal tension glaucomaOptineurinRetinaVisual function

Identifiers

PMID39208752
PMCPMC13379292

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.