Evidence map›Paper›PMID 39208693›Full record

ArticleDrug and alcohol dependence2024

Sex differences in distributed error-related neural activation in problem-drinking young adults.

Jillian E Hardee, Alexander S Weigard, Mary M Heitzeg, Meghan E Martz, Lora M Cope

Abstract read
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In one paragraph

Article in Drug and alcohol dependence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jillian E HardeeDepartment of Psychiatry and Addiction Center, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109, USA. Electronic address: jhardee@med.umich.edu.
Alexander S WeigardDepartment of Psychiatry and Addiction Center, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109, USA.
Mary M HeitzegDepartment of Psychiatry and Addiction Center, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109, USA.
Meghan E MartzDepartment of Psychiatry and Addiction Center, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109, USA.
Lora M CopeDepartment of Psychiatry and Addiction Center, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109, USA.

Funding

Leveraging computational models of neurocognition to improve predictions about individual youths' risk for substance use disordersK23DA051561 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIGARD, ALEXANDER · 2021 to 2025
$983k
Sex differences in the neural mechanisms of brief interventions for binge drinkingK01AA024804 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARDEE, JILLIAN ELIZABETH · 2016 to 2020
$830k
Developmental and sex differences in modulation of nucleus accumbens activationK01AA027558 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTZ, MEGHAN ELIZABETH · 2019 to 2023
$826k
NIAAA NIH HHS K01 AA024804NIAAA NIH HHS K01 AA027558NIDA NIH HHS K23 DA051561
6 · The paper itself

Abstract

backgroundDetecting and responding to errors is central to goal-directed behavior and cognitive control and is thought to be supported by a network of structures that includes the anterior cingulate cortex and anterior insula. Sex differences in the maturational timing of cognitive control systems create differential periods of vulnerability for psychiatric conditions, such as substance use disorders.

methodsWe examined sex differences in error-related activation across an array of distributed brain regions during a Go/No-Go task in young adults with problem alcohol use (N=69; 34 females; M=19.4 years). Regions of interest previously linked to error-related activation, including anterior cingulate cortex, insula, and frontoparietal structures, were selected in a term-based meta-analysis. Individual differences in their responses to false alarm (FA) inhibitory errors relative to "go" trials (FA>GO) and correct rejections (FA>CR) were indexed using multivariate summary measures derived from principal components analysis.

resultsFA>GO and FA>CR activation both revealed a first component that explained the majority of the variance across error-associated regions and displayed the strongest loadings on salience network structures. Compared to females, males exhibited significantly higher levels of the FA>GO component but not the FA>CR component.

conclusionsMales exhibit greater salience network activation in response to inhibitory errors, which could be attributed to sex differences in error-monitoring processes or to other functions (e.g., novelty detection). The findings are relevant for the further characterization of sex differences in cognitive control and may have implications for understanding individual differences in those at risk for substance use or other cognitive control disorders.

Indexed as

Magnetic Resonance ImagingSex CharacteristicsAdolescentAdultAlcoholismBrainBrain MappingFemaleGyrus CinguliHumansInhibition, PsychologicalMaleYoung AdultAlcohol useFalse alarmsFMRIPrincipal components analysisSex differences

Identifiers

PMID39208693
PMCPMC11500318

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.