Evidence map›Paper›PMID 39208497›Full record

ArticleBiomaterials advances2024

Sustained dual delivery of metronidazole and viable Lactobacillus crispatus from 3D-printed silicone shells.

Anthony J Kyser, Mohamed Y Mahmoud, Bassam Fotouh, Rudra Patel, Christy Armstrong, Marnie Aagard, Isaiah Rush, Warren Lewis, Amanda Lewis, Hermann B Frieboes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anthony J KyserDepartment of Bioengineering, University of Louisville, Louisville, KY, USA.
Mohamed Y MahmoudDepartment of Bioengineering, University of Louisville, Louisville, KY, USA; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Egypt.
Bassam FotouhDepartment of Bioengineering, University of Louisville, Louisville, KY, USA.
Rudra PatelDepartment of Bioengineering, University of Louisville, Louisville, KY, USA.
Christy ArmstrongGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.
Marnie AagardGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.
Isaiah RushDepartment of Chemical Engineering, University of Dayton, Dayton, OH, USA.
Warren LewisGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.
Amanda LewisGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.
Hermann B FrieboesDepartment of Bioengineering, University of Louisville, Louisville, KY, USA; Center for Predictive Medicine, University of Louisville, Louisville, KY, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA; UofL Health - Brown Cancer Center, University of Louisville, KY, USA. Electronic address: hbfrie01@louisville.edu.

Funding

ROLES OF SIALIDASE IN G. VAGINALIS-HOST INTERACTIONS DURING BACTERIAL VAGINOSISR01AI114635 · NIAID · WASHINGTON UNIVERSITY · PI LEWIS, AMANDA L., LEWIS, WARREN G · 2015 to 2025
$5.9M
3D-bioprinting of sustained- and phased-release antibiotic and probiotic scaffolds to treat bacterial vaginosisR01AI168475 · NIAID · UNIVERSITY OF LOUISVILLE · PI FRIEBOES, HERMANN, LEWIS, AMANDA L. · 2022 to 2025
$3.0M
NIAID NIH HHS R01 AI114635NIAID NIH HHS R01 AI168475
6 · The paper itself

Abstract

Bacterial vaginosis (BV) is an imbalance of the vaginal microbiome in which there are limited lactobacilli and an overgrowth of anaerobic and fastidious bacteria such as Gardnerella. The propensity for BV recurrence is high, and therapies involving multiple treatment modalities are emerging to meet this need. However, current treatments requiring frequent therapeutic administration are challenging for patients and impact user compliance. Three-dimensional (3D)-printing offers a novel alternative to customize platforms to facilitate sustained therapeutic delivery to the vaginal tract. This study designed a novel vehicle intended for dual sustained delivery of both antibiotic and probiotic. 3D-printed compartmental scaffolds consisting of an antibiotic-containing silicone shell and a core containing probiotic Lactobacillus were developed with multiple formulations including biomaterials sodium alginate (SA), polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyethylene oxide (PEO), and kappa-carrageenan (KC). The vehicles were loaded with 50 μg of metronidazole/mg polymer and 5 × 10

Indexed as

Lactobacillus crispatusMetronidazolePrinting, Three-DimensionalProbioticsSiliconesAnti-Bacterial AgentsDelayed-Action PreparationsDrug Delivery SystemsDrug LiberationFemaleHumansVaginosis, BacterialAnti-Bacterial AgentsDelayed-Action PreparationsMetronidazoleSilicones3D-printingAntibioticsBacterial vaginosisLactobacillusProbioticsVaginal drug delivery

Identifiers

PMID39208497
PMCPMC11443601

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.