Evidence map›Paper›PMID 39208375›Full record

ArticleJCO precision oncology2024

False-Positive Circulating Tumor DNA Results Do Not Explain Lack of Efficacy for PARP Inhibitors in Patients With Castration-Resistant Prostate Cancer Harboring

Jaleh Fallah, Jianjin Xu, Hee-Koung Joeng, Chana Weinstock, Brian L Heiss, William F Maguire, Xin Gao, Joyce Cheng, Elaine Chang, Sundeep Agrawal and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCO precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jaleh FallahCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0001-7365-2104
Jianjin XuCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0001-9312-6339
Hee-Koung JoengCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.
Chana WeinstockCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.
Brian L HeissCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0002-7858-841X
William F MaguireCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0002-3288-8863
Xin GaoCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0002-7383-6453
Joyce ChengCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.
Elaine ChangCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0001-6255-2853
Sundeep AgrawalCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.
Mallorie H FieroCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.
Richard PazdurCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0002-4771-9923
Paul G KluetzCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.
Laleh Amiri-KordestaniCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.ORCID 0000-0002-0056-5437
Daniel L SuzmanCenter for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

False-positive ctDNA results do not explain lack of efficacy for PARPi in patients with ATMm and CHEK2m CRPC.

Indexed as

Ataxia Telangiectasia Mutated ProteinsCheckpoint Kinase 2Circulating Tumor DNAMutationPoly(ADP-ribose) Polymerase InhibitorsProstatic Neoplasms, Castration-ResistantAgedFalse Positive ReactionsHumansMaleMiddle AgedAtaxia Telangiectasia Mutated ProteinsATM protein, humanCheckpoint Kinase 2CHEK2 protein, humanCirculating Tumor DNAPoly(ADP-ribose) Polymerase Inhibitors

Identifiers

PMID39208375
PMCPMC11371381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.