ArticlePloS one2024
Prognostic value of systemic inflammatory response index for acute kidney injury and the prognosis of pediatric patients in critical care units.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The predictive value of early systemic inflammatory response index (SIRI), serum βRenal failure · 2026Article
- Machine learning early risk assessment model for acute kidney injury in critically ill children: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Short-term outcome and prognostic factors in acute fulminant myocarditis with acute kidney injury patients.Frontiers in medicine · 2026Article
- Article
- The Systemic Inflammation Response Index as an Independent Predictor of Acute Kidney Injury in Critically Ill Patients With Acute Myocardial Infarction: Insights From a Large-Scale Cohort Study.Mediators of inflammation · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundWe proposed a link between the first systemic inflammatory response index (SIRI) and acute kidney injury (AKI), as well as the prognosis of pediatric patients in intensive care units (PICU).
methodsThis study comprised 5114 children from the pediatric-specific intensive care (PIC) database. SIRI was estimated as a neutrophil monocyte lymphocyte ratio. All patients were arbitrarily allocated to the training set (n = 3593) and the validation cohort (n = 1521) and divided into two groups depending on their SIRI levels. The diagnostic value of SIRI for pediatric ICU patients was subsequently determined using LASSO regression models.
resultsAfter controlling for additional confounding variables in the training set, the higher SIRI value (≥ 0.59) had a greater risk of AKI (adjusted odds ratio, OR, 3.95, 95% confidence interval, 95%CI, 2.91-5.36, P<0.001) and in-hospital mortality (hazard ratio, HR, 5.01, 95%CI 2.09-12.03, P<0.001). Similar findings were discovered in the validation set. Furthermore, the suggested nomogram derived from SIRI and other clinical metrics showed outstanding calibration capability as well as therapeutic usefulness in both groups.
conclusionsSIRI is a reliable and useful factor for AKI and fatality in pediatric ICU patients, and the proposed nomogram based on SIRI yields an appropriate prediction value for critically sick pediatric patients.
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