Evidence map›Paper›PMID 39208242›Full record

ArticlePloS one2024

Wavelet phase coherence of ictal scalp EEG-extracted muscle activity (SMA) as a biomarker for sudden unexpected death in epilepsy (SUDEP).

Adam C Gravitis, Krishram Sivendiran, Uilki Tufa, Katherine Zukotynski, Yotin Chinvarun, Orrin Devinsky, Richard Wennberg, Peter L Carlen, Berj L Bardakjian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam C GravitisInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9178-5496
Krishram SivendiranInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Uilki TufaInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Katherine ZukotynskiDepartment of Radiology, McMaster University, Hamilton, Ontario, Canada.
Yotin ChinvarunDepartment of Medicine, Phramongkutklao Royal Army Hospital, Bangkok, Thailand.
Orrin DevinskyGrossman School of Medicine, New York University, New York, New York, United States of America.ORCID 0000-0003-0044-4632
Richard WennbergDepartment of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.
Peter L CarlenInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Berj L BardakjianInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9969-4775

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveApproximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with epilepsy are attributed to sudden unexpected death in epilepsy (SUDEP). The goal of the present work was to establish a biomarker for SUDEP so that preventive treatment can be instituted. APPROACH: Seizure activity in patients with SUDEP and non-SUDEP was analyzed, specifically, the scalp EEG extracted muscle activity (SMA) and the average wavelet phase coherence (WPC) during seizures was computed for two frequency ranges (1-12 Hz, 13-30 Hz) to identify differences between the two groups. MAIN

resultsIctal SMA in SUDEP patients showed a statistically higher average WPC value when compared to non-SUDEP patients for both frequency ranges. Area under curve for a cross-validated logistic classifier was 81%. SIGNIFICANCE: Average WPC of ictal SMA is a candidate biomarker for early detection of SUDEP.

Indexed as

BiomarkersElectroencephalographySudden Unexpected Death in EpilepsyAdolescentAdultEpilepsyFemaleHumansMaleMiddle AgedScalpSeizuresWavelet AnalysisYoung AdultBiomarkers

Identifiers

PMID39208242
PMCPMC11361603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.