Evidence map›Paper›PMID 39208189›Full record

ArticlePloS one2024

A protracted cholera outbreak in Nairobi City County accentuated by mass gathering events, Kenya, 2017.

Philip Ngere, Daniel Langat, Isaac Ngere, Jeanette Dawa, Emmanuel Okunga, Carolyne Nasimiyu, Catherine Kiama, Peter Lokamar, Carol Ngunu, Lyndah Makayotto and 2 more

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Philip NgereWashington State University Global Health Program, Nairobi City, Kenya.ORCID 0009-0004-6164-7972
Daniel LangatDivision of Disease Surveillance and Response, Ministry of Health, Nairobi City, Kenya.
Isaac NgereWashington State University Global Health Program, Nairobi City, Kenya.ORCID 0000-0002-6688-3390
Jeanette DawaWashington State University Global Health Program, Nairobi City, Kenya.
Emmanuel OkungaDivision of Disease Surveillance and Response, Ministry of Health, Nairobi City, Kenya.
Carolyne NasimiyuWashington State University Global Health Program, Nairobi City, Kenya.ORCID 0000-0002-7559-3109
Catherine KiamaWashington State University Global Health Program, Nairobi City, Kenya.
Peter LokamarNational Public Health Laboratory Services, Ministry of Health, Nairobi City, Kenya.
Carol NgunuDepartment of Health Services, Nairobi City County Government, Nairobi City, Kenya.
Lyndah MakayottoDivision of Disease Surveillance and Response, Ministry of Health, Nairobi City, Kenya.
M Kariuki NjengaWashington State University Global Health Program, Nairobi City, Kenya.
Eric OsoroWashington State University Global Health Program, Nairobi City, Kenya.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholera continues to cause many outbreaks in low and middle-income countries due to inadequate water, sanitation, and hygiene services. We describe a protracted cholera outbreak in Nairobi City County, Kenya in 2017. We reviewed the cholera outbreak line lists from Nairobi City County in 2017 to determine its extent and factors associated with death. A suspected case of cholera was any person aged >2 years old who had acute watery diarrhea, nausea, or vomiting, whereas a confirmed case was where Vibrio cholerae was isolated from the stool specimen. We summarized cases using means for continuous variables and proportions for categorical variables. Associations between admission status, sex, age, residence, time to care seeking, and outbreak settings; and cholera associated deaths were assessed using odds ratio (OR) with 95% confidence interval (CI). Of the 2,737 cholera cases reported, we analyzed 2,347 (85.7%) cases including 1,364 (58.1%) outpatients, 1,724 (73.5%) not associated with mass gathering events, 1,356 (57.8%) male and 2,202 (93.8%) aged ≥5 years, and 35 deaths (case fatality rate: 1.5%). Cases were reported from all the Sub Counties of Nairobi City County with an overall county attack rate of 50 per 100,000 people. Vibrio cholerae Ogawa serotype was isolated from 78 (34.8%) of the 224 specimens tested and all isolates were sensitive to tetracycline and levofloxacin but resistant to amikacin. The odds of cholera-related deaths was lower among outpatient cases (aOR: 0.35; [95% CI: 0.17-0.72]), age ≥5 years old (aOR: 0.21 [95% CI: 0.09-0.55]), and mass gathering events (aOR: 0.26 [95% CI: 0.07-0.91]) while threefold higher odds among male (aOR: 3.04 [95% CI: 1.30-7.13]). Nairobi City County experienced a protracted and widespread cholera outbreak with a high case fatality rate in 2017.

Indexed as

CholeraDisease OutbreaksVibrio choleraeAdolescentAdultAgedAnti-Bacterial AgentsChildChild, PreschoolFemaleHumansKenyaMaleMiddle AgedYoung AdultAnti-Bacterial Agents

Identifiers

PMID39208189
PMCPMC11361576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.