ArticleCell reports2024
Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- A novel superior colliculus circuit mediates visual cue-driven methamphetamine taking and seeking.Acta pharmacologica Sinica · 2026Article
- Article
- The Role of the Ventral Tegmental Area in Reward and Addiction: A Comprehensive Review.Neurosciences (Riyadh, Saudi Arabia) · 2026Review
- Reward-associated cues reduce H-current amplitude in midbrain dopamine neurons.Neuropharmacology · 2025Article
- Projection-defined ventral tegmental area neurons exhibit fentanyl-induced molecular and functional adaptations that differentially support drug-context associations.bioRxiv : the preprint server for biology · 2025Article
- Ventral tegmental area GABA neurons integrate positive and negative valence.Nature communications · 2025Article
- Ventral tegmental area GABA neurons integrate positive and negative valence.bioRxiv : the preprint server for biology · 2025Article
- Flexible updating of reward and punishment contingencies by VTA GABA neurons.Current biology : CB · 2025Article
- Obtaining artifact-corrected signals in fiber photometry via isosbestic signals, robust regression, and dF/F calculations.Neurophotonics · 2025Article
- Zona incerta: from Parkinson's disease to addiction.Frontiers in neural circuits · 2025Article
- Dopamine transients encode reward prediction errors independent of learning rates.Cell reports · 2024Article
- Dopamine transients encode reward prediction errors independent of learning rates.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Ventral tegmental area (VTA) dopamine neurons regulate reward-related associative learning and reward-driven motivated behaviors, but how these processes are coordinated by distinct VTA neuronal subpopulations remains unresolved. Here, we compare the contribution of two primarily dopaminergic and largely non-overlapping VTA subpopulations, all VTA dopamine neurons and VTA GABAergic neurons of the mouse midbrain, to these processes. We find that the dopamine subpopulation that projects to the nucleus accumbens (NAc) core preferentially encodes reward-predictive cues and prediction errors. In contrast, the subpopulation that projects to the NAc shell preferentially encodes goal-directed actions and relative reward anticipation. VTA GABA neuron activity strongly contrasts VTA dopamine population activity and preferentially encodes reward outcome and retrieval. Electrophysiology, targeted optogenetics, and whole-brain input mapping reveal multiple convergent sources that contribute to the heterogeneity among VTA dopamine subpopulations that likely underlies their distinct encoding of reward-related associations and motivation that defines their functions in these contexts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.